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Population Descriptors for Legacy Genomic Data: Challenges and Future Directions

Event Details

Several National Institutes of Health (NIH) Institutes, Offices, and Centers* are partnering to host a two-day virtual workshop on May 28-29, 2024, to further explore the recommendations from the National Academies of Sciences, Engineering and Medicine (NASEM) 2023 report, Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field, with regards to legacy genomic data. 

This workshop will bring together leaders of genomic data science resources, researchers who use legacy data, and other partners to make recommendations regarding the application of population descriptors to existing data. A meeting report will be written and disseminated publicly. 

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Objectives

The workshop objectives are to:

  • • Understand NASEM report recommendations, and consider how they relate to the ongoing use of legacy data; 
  • • Summarize current approaches to the use of population descriptors in/for legacy data;   
  • • Define challenges with current approaches to harmonization, interoperability and analysis, including genetic similarity;  
  • • Address challenges and identify potential solutions;  
  • • Develop practical recommendations that can be widely adopted; and 
  • • Identify opportunities for future research or collaboration.

For more information, please contact: Lucia Hindorff (hindorffl@mail.nih.gov) or Joannella Morales (joannella.morales@nih.gov).

Agenda

All times listed in ET.

Day 1: May 28, 2024

  • 1:00 - 1:05 PM - Welcome
    Lucia Hindorff and Joanella Morales
    National Human Genome Research Institute
  • 1:05 - 1:15 PM - Workshop Purpose and Objectives
    Vence Bonham, National Human Genome Research Institute
    Sheri Schully, All of Us Research Program
  • 1:15 - 1:35 PM - Population Descriptors in Genomic Legacy Data
    Melissa Davis, Morehouse School of Medicine 
    Malia Fullerton, University of Washington
  • 1:35 - 1:55 PM - Introduction to the NASEM Report: Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field
    Genevieve Wojcik, Johns Hopkins Bloomberg School of Public Health
  • 1:55 - 2:25 PM - Lessons learned from the All of Us Research Program
    Anjené Musick, All of Us Research Program
    Eric Boerwinkle, UTHealth Houston School of Public Health
  • 2:25 - 2:40 PM - Break
  • 2:40 - 3:25 PM - Panel: Current challenges related to population descriptors in select contexts
    Panelists:
    Katherine Chao: Broad Institute
    Charles Rotimi, National Human Genome Research Institute
    Kyle Brothers, University of Louisville
  • 3:25 - 4:10 PM - Breakout Groups: Additional challenges related to population descriptors in genomic legacy data
    Moderated Discussion
  • 4:10 - 4:50 PM - Large Group Discussion: Breakout Groups Report Back 
    Moderated Discussion
  • 4:50 - 5:00 PM - End of Day 1 Check-In
    Melissa Davis, Morehouse School of Medicine 
    Malia Fullerton, University of Washington

 

Day 2: May 29, 2024

  • 11:00 - 11:05 AM - Welcome to Day 2
    Melissa Davis, Morehouse School of Medicine 
    Malia Fullerton, University of Washington
  • 11:05 - 11:25 AM - Population Inferences and Genetic Similarity
    Peter Kraft, National Cancer Institute
  • 11:25 - 12:00 PM - Panel: Addressing challenges related to harmonization and interoperability of legacy genomic data
    John Witte, Stanford University
    Karen Miga, University of California, Santa Cruz
  • 12:00 - 12:10 PM - Break
  • 12:10 - 12:30 - Adapting the NASEM Report framework to legacy data
    John Novembre, University of Chicago
  • 12:30 - 1:15 PM - Breakout Groups: Adapting the NASEM Report framework to legacy data through the lense of distinct use cases
    Moderated Discussion
  • 1:15 - 1:55 PM - Large Group Discussion: Breakout Groups Report Back 
    Moderated Discussion
  • 1:55 - 2:05 PM - Break
  • 2:05 - 3:00 PM - Summary of Workshop / Recommendations and Discussions
    Melissa Davis, Morehouse School of Medicine 
    Malia Fullerton, University of Washington

*Participating NIH Institutes, Centers and Offices

All of Us Research Program
National Cancer Institute
National Human Genome Research Institute
National Institute on Aging
National Institute of Child Health and Human Development
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Environmental Health Sciences
National Institute of Nursing Research
Office of Behavioral and Social Sciences Research 
Office of Science Policy

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Request an Accommodation

Sign language interpreting and CART services are available upon request to participate in this event. Individuals needing either of these services and/or other reasonable accommodations should contact Britny Kish at britny.kish@nih.gov, 240-381-1283. Requests should be made at least five days in advance. To access Telecommunications Relay Services (TRS), call 711. 

Last updated: April 19, 2024