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Fabio Candotti, M.D.
Selected Publications
Otsu M, Sugamura K, Candotti F. Lack of dominant-negative effects of a truncated gamma(c) on retroviral-mediated gene correction of immunodeficient mice. Blood, 97:1618. 2001. [PubMed]
Wada T, Schurman SH, Otsu M, Garabedian EK, Ochs HD, Nelson DL, Candotti F. Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism. Proc Natl Acad Sci U S A, 98(15):8697-702. 2001. [PubMed]
Wada T., Jagadeesh G.J., Nelson L.D., Candotti F.: Retrovirus-mediated WASP gene transfer corrects Wiskott-Aldrich syndrome T cell dysfunction. Hum Gene Ther, 13:1039-1046. 2002. [PubMed]
Muul L.M., Tuschong L.M., Soenen S.L., Jagadeesh G.J., Ramsey W.J., Long Z., Carter C.S., Garabedian E.K., Alleyne M., Brown M., Bernstein W., Schurman S.H., Fleisher T.A., Leitman S.F., Dunbar C.E., Blaese R.M., Candotti F. Persistence and expression of the adenosine deaminase gene for twelve years and immune reaction to gene transfer components: Long-term results of the first clinical gene therapy trial. Blood, 101:2563-2569. 2003. [PubMed]
Shcherbina A., Candotti F., Rosen F.S., Remold-O¿Donnell E. High incidence of lymphomas in a subgroup of Wiskott-Aldrich syndrome patients. Br J Haematol 121:529¿530, 2003. [PubMed]
Schurman S.H., Candotti F. Autoimmunity in the Wiskott-Aldrich syndrome. Curr Opin Rheumatol 15:446¿453, 2003. [PubMed]
Wada T., Konno A., Schurman S.H., Garabedian E.K., Anderson S.M., Kirby M., Nelson D.L., Candotti F.: Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings. J Clin Invest, 111:1389-1397. 2003. [PubMed]
Bosticardo M., Witte I., Fieschi C., Novelli F., Casanova J.L., Candotti F.
Retroviral-mediated gene transfer restores IL-12 and IL-23 signaling
pathways in T cells from IL-12 receptor beta1-deficient patients.
Mol Ther, (6):895-901. 2004. [PubMed]
Konno A., Wada T., Schurman S.H., Garabedian E.K., Kirby M., Anderson S.M.,
Candotti F. Differential contribution of Wiskott-Aldrich syndrome protein to
selective advantage in T- and B-cell lineages. Blood, 103(2):676-8. 2004. [PubMed]
Wada T., Schurman S.H., Jagadeesh G.J., Garabedian E.K., Nelson D.L., Candotti F.
Multiple patients with revertant mosaicism in a single Wiskott-Aldrich
syndrome family. Blood, 104(5):1270-2. 2004. [PubMed]
Fieschi C., Bosticardo M., de Beaucoudrey L., Dupuis S., Feinberg J., dos Santos O., Bustamante J., Levy J., Candotti F., Casanova J.L. A novel form of complete IL-12/IL-23 receptor ²1-deficiency with cell surfaceexpressed non-functional receptors. Blood, 104:2095-2101. 2004. [PubMed]
Wada T., Schurman S.H., Garabedian E.K., Yachie A., Candotti F. Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Blood, 106(12):3895-7. 2005. [PubMed]
Puck, J.M., Candotti, F., Lessons from the Wiskott-Aldrich syndrome.
N Engl J Med, 355(17):1759-61. 2006. [FullText]
Konno, A., Kirby, M., Anderson, S.A., Schwartzberg, P.L., Candotti, F. The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP).
Int Immunol, 19(2):185-92. 2007. [PubMed]
Adriani, M., Aoki, J., Horai, R., Thornton, A.M., Konno, A., Kirby, M., Anderson, S.M., Siegel, R.M., Candotti, F., Schwartzberg, P.L.
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome.
Clin Immunol, 124(1):41-8. 2007 . [PubMed]
Lagresle-Peyrou C., Six E.M., Picard C., Rieux-Laucat F., Michel V., Ditadi A., Demerens-de Chappedelaine C., Morillon E., Valensi F., Simon-Stoos K.L., Mullikin J.C., Noroski L.M., Besse C., Wulffraat N.M., Ferster A., Abecasis M.M., Calvo F., Petit C., Candotti F., Abel L., Fischer A., Cavazzana-Calvo M. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet, 41:106-11. 2009. [PubMed]
Kohn D.B., Candotti F.: Gene therapy fulfilling its promise. N Engl J Med, 360:518-521.43. 2009. [PubMed]
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Last Updated: August 27, 2009
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