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Julie A. Segre, Ph.D.
Selected Publications
Segre J.A, Nemhauser J.L, Taylor B.A., Nadeau J.H., Lander E.S.. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics, 28(3): 549-59. 1995. [PubMed]
Segre J.A., Bauer C., Fuchs E. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet, 22(4): 356-60. 1999. [PubMed]
Fuchs E., Segre J.A. Stem cells: a new lease on life. Cell, 100(1): 143-55. 2000. [PubMed]
Jaubert J., Cheng J., Segre J.A. Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development, (12):2767-77. 2003. [PubMed]
Segre J.A. Complex redundancy to build a simple epidermal permeability barrier. Current Opinion in Cell Biology, 15: 778-784. 2003. [PubMed]
Dai X., Segre J.A. Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev, 14(5):485-91. 2004. [PubMed]
Jaubert J., Patel S., Cheng J., Segre J.A. Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression.
J Invest Dermatol, 123(2):313-8. 2004. [PubMed]
Martin, N., Patel, S. and Segre, J.A. Long-Range Comparison of
Human and Mouse Sprr Loci to Identify Conserved Noncoding Sequences
Involved in Coordinate Regulation. Genome Res, (12):2430-8. 2004. [PubMed]
Segre, J.A. Epidermal barrier formation and recovery in skin disorders. J. Clin. Invest. 2006; 116(5): 1150-8. [PubMed]
Segre, J.A. Epidermal Differentiation Complex yields a secret: Mutations in the cornification protein Filaggrin underlie ichthyosis vulgaris. J Invest Dermatol. 2006; 126(6):1202-4. [PubMed]
Patel, S., Xi, Z.F., Seo, E.Y., McGaughey, D., Segre, J.A. Klf4 and Corticosteroids Activate an Overlapping Set of Transcriptional Targets to Accelerate in utero Epidermal Barrier Acquisition. Proc Natl Acad Sci, 103(49):18668-73. 2006. [PubMed]
de Guzman Strong, C., Wertz, P.W., Wang, C., Yang, F. Meltzer, P.S., Andl, T., Millar, S.E., Ho, I.-C., Pai, S.-Y., and Segre, J.A. Defect Underlies Selective Barrier Deficiency of an Epidermal-specific Deletion of Gata-3. J Cell Biol, 175(4):661-70. 2006. [Full Text] 
de Guzman Strong C, Segre JA. Navigating the genome. J Cell Sci, 1;121(Pt 7):921-3. 2008. [PubMed]
Scharschmidt TC, Segre JA. Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol, 128(5):1061-4. 2008. [PubMed]
Grice EA, Kong HH, Renaud G, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Wolfsberg TG, Turner ML, Segre JA. A diversity profile of the human skin microbiota. Genome Res, 18(7):1043-50. 2008. [PubMed]
Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA. Topographical and temporal diversity of the human skin microbiome. Science, 324(5931):1190-2. 2009. [PubMed]
Scharschmidt TC, List K, Grice EA, Szabo R; NISC Comparative Sequencing Program, Renaud G, Lee CC, Wolfsberg TG, Bugge TH, Segre JA. Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol, 129(10):2435-42. 2009. [PubMed]
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Last Updated: September 24, 2009
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