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T Lymphocyte Signaling and Primary Immunodeficiencies: Lessons from X-linked Lymphoproliferative Disease
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Tuesday, May 13, 2008
8:00 AM - 9:00 AM
Lecture
Pamela L. Schwartzberg, M.D., Ph.D.
NCI Center for Cancer Research GRAND ROUNDS
DATE: Tuesday, May 13, 2008, 8:00-9:00 a.m.
SPEAKER:
Pamela L. Schwartzberg, M.D., Ph.D.
Senior Investigator and Head, Cell Signaling Section
Genetic Disease Research Branch
NHGRI
LECTURE TITLE: "T Lymphocyte Signaling and Primary Immunodeficiencies: Lessons from X-linked Lymphoproliferative Disease"
LOCATION: LIPSETT AMPHITHEATER, Building 10
ABOUT THE SPEAKER: Dr. Schwartzberg received her M.D. and Ph.D. in the Medical
Scientist Training Program at Columbia College of Physicians and Surgeons,
Columbia University, New York. She was an intern in pediatrics at Children?s Hospital, Boston, and a post-doctoral fellow under Drs. Harold Varmus and Dr.
Michael Lenardo at NIH, where she was a Leukemia Society of America special fellow. Dr. Schwartzberg then joined the Genetic Disease Research Branch of the National Human Genome Research Institute (NHGRI) as a tenure track investigator and rose to the position of senior investigator and head of the cell signaling section. Dr. Schwartzberg's graduate work made important contributions to two
areas: 1) understanding retroviral replication and 2) generation of gene-targeted mice using mouse embryonic stem cells. The major focus of her laboratory is how altered signaling affects T lymphocyte development and responses to infectious disease, with the aim of providing models for potential therapeutic targets. Her work also centers on mouse models of human primary T cell immune disorders, including X-linked lymphoproliferative disease, with the goal of providing clinical insight to these diseases. She has published more than 65 peer-reviewed articles and was awarded the B-D Pharmigen Award from the American Association of Immunologists and elected to the American Association of Physicians in April 2008.
SELECTED REFERENCES:
1. Czar, MJ, Kersh, E, Mijares, LA, Lanier, G, Lewis, J,Yap, G, Chen, A,
Sher, A, Duckett, C, Ahmed, R, and Schwartzberg, PL: Altered Lymphocyte Regulation and Cytokine Production in SAP(-) mice: A potential model for X-Linked Proliferative Disease. Proc. Natl Acad. Sci. USA 98:7449-7454, 2001.
2. Crotty, S, Kersh, EN, Cannons, J, Schwartzberg, PL, and Ahmed, R: SAP
is required for the generation of long-term humoral immunity. Nature.
421:282-287, 2003.
3. Cannons, JL, Yu, LJ, Jankovic, D, Crotty, S, Horai, R, Kirby, M,
Anderson, S, Cheever, AW, Sher, A, and Schwartzberg, PL: T cell-mediated Humoral Immune Regulation by SAP: Evidence for a mechanism Independent of cytokine regulation. J. Exp. Med. 203: 1551-1565, 2006.
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of The Johns Hopkins University School of Medicine and The National Institutes of Health. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 38 AMA PRA Category 1 Credit(s)?. Physicians should only claim credit commensurate with the extent of their participation in the activity.
EDUCATIONAL OBJECTIVES
After attending this activity, the participant should be able to:
? describe features of X-linked lymphoproliferative disease
TARGET AUDIENCE
NIH scientists, clinicians, and fellows
REASONABLE ACCOMMODATION
Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this event should contact Karen Davison, Matthews Media Group, at 301-984-7191 and/or the Federal Relay (1-800-877-8339). Requests should be made at least 1 business day in advance of the event.
FULL DISCLOSURE STATEMENT
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of The Johns Hopkins University School of Medicine to require the disclosure of the existence of any significant financial interest or any other relationship a faculty member or a provider has with the manufacturer(s) of any commercial product(s) discussed in an educational presentation. The presenting faculty reported the following:
1. Planning committee members: Drs. L.M. Bennett, M. Bishop, D. Bottaro,
K. Camphausen, G. Giaccone, J. Gulley, R. Hassan, K. Hunter, K. Kelly, J. Khan, D. Levens, Y. Pommier, T. Reid, D. Schrump, and J. Vogel have no relevant relationships to this educational presentation.
2. The speaker for this activity reports nothing to disclose.
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health
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Evolution and Human Genetic Diversity: Tales from Africa
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Tuesday, May 13, 2008
12:00 PM - 1:00 PM
Lecture
Sarah Tishkoff
The genomes of contemporary humans were shaped by evolutionary forces, such as mutation, selection, migration, and genetic drift. Because Africa plays a central role in the story of human evolution, research there is yielding a wealth of knowledge about human origins and diversity as well as a deeper understanding of evolutionary processes. Dr. Tishkoff has conducted ground-breaking research on African genetic diversity and the genetic basis of adaptation in humans.
The National Institute of General Medical Sciences (NIGMS) and the Office of Science Education (OSE) are partnering to present a four-part lecture series, Evolution and Medicine. Each guest speaker will examine the role of evolution as it applies to their area of scientific expertise. The series is open to all NIH employees and the public. No registration is required.
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Evolution and the Concept of Species
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Tuesday, May 27, 2008
12:00 PM - 1:00 PM
Lecture
Mohamed Noor
The National Institute of General Medical Sciences (NIGMS) and the Office of Science Education (OSE) are partnering to present a four-part lecture series, Evolution and Medicine. Each guest speaker will examine the role of evolution as it applies to their area of scientific expertise. The series is open to all NIH employees and the public. No registration is required.
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Evolution and Biological Systems
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Tuesday, June 10, 2008
12:00 PM - 1:00 PM
Lecture
Christopher Marx
The National Institute of General Medical Sciences (NIGMS) and the Office of Science Education (OSE) are partnering to present a four-part lecture series, Evolution and Medicine. Each guest speaker will examine the role of evolution as it applies to their area of scientific expertise. The series is open to all NIH employees and the public. No registration is required.
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The Evolution of Protein Structure and Function
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Tuesday, June 24, 2008
12:00 PM - 1:00 PM
Lecture
Joe Thornton
The National Institute of General Medical Sciences (NIGMS) and the Office of Science Education (OSE) are partnering to present a four-part lecture series, Evolution and Medicine. Each guest speaker will examine the role of evolution as it applies to their area of scientific expertise. The series is open to all NIH employees and the public. No registration is required.
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DIR Seminar Series
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Thursday, September 25, 2008
11:00 AM - 12:00 PM
Joe Gray, Ph.D.
Building 50
first floor conference room
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DIR Seminar Series
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Thursday, November 6, 2008
11:00 AM - 12:00 PM
Jonathon Pritchard, Ph.D.
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DIR Seminar Series
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Thursday, December 11, 2008
11:00 AM - 12:00 PM
Albert de la Chapelle, M.D., Ph.D.
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