Previous Genomic Sequencing Targets
September 2006
At the end of September 2006, the Council approved the following consensus recommendation of priorities for the NHGRI sequencing program:
| Mammalian Genomes | | | | Macaca mulatta (Macaque) | 3,000 | Y chromosome refinement | | Callithrix jacchus (Marmoset) | 3,000 | Y chromosome refinement | | Rattus norvegicus (Rat) | 3,000 | Y chromosome refinement | | Bos taurus (Cow) | 3,000 | Y chromosome refinement | | Monodelphis domestica (Opossum) | 3,000 | Y chromosome refinement | | Non-Mammalian Genomes | | | | Tilapia Cichlid | 4 species,
each 106 | Draft assembly of tilapia,
2-fold coverage of 3 species | | Strongylid Worms | 10 species,
each 55 | Draft assembly of 5 species,
2-fold coverage of 3 species | Evolution of the Proteome
(Painted turtle, Coelacanth, Spotted gar, Hagfish and Skate) | 5 species,
each vary | Draft assembly | |
May 2006
At the end of May 2006, the Council approved the following consensus recommendation of priorities for the NHGRI sequencing program:
| Mammalian Genomes | | | | Nomascus leucogenys (Gibbon) | 3,000 | Draft assembly | | Dasypus novemcinctus (Armadillo) | 3,000 | Draft assembly | | Felis catus (Cat) | 3,000 | Draft assembly | | Cavia Porcellus (Guinea Pig) | 3,000 | Draft assembly | | Loxodonta africana africana (Elephant) | 3,000 | Draft assembly | | Myotis lucifugus (Little brown bat) | 3,000 | Draft assembly | | Tupaia belangeri (Tree shrew) | 3,000 | Draft assembly | | Oryctolagus cuniculus (Rabbit) | 3,000 | Draft assembly | |
| Non-Mammalian Species | |   |
| Dermatophyte fungi (5) | 5 species, each 30 | Draft assembly of 3 species, 2-fold coverage of 2 species |
| Origins of Multicellularity Project (10) | 10 species, each vary | Draft assembly of 5 species, 2-fold coverage of 5 species |
| Saccharomyces cerevisiae (Yeast) | Up to 35 species, 12 each | 10 strains to full draft, 2-fold coverage of up to 25 stains coverage |
February 2006
At the end of February 2006, the Council approved the following consensus recommendation of priorities for the NHGRI sequencing program:
| Mammalian Species | | | | Elephantulus sp.(Elephant Shrew) | 3,000 | 2-fold genome coverage | | Dermoptera sp. (Flying lemur) | 3,000 | 2-fold genome coverage | | Tursiops truncates (Dolphin) | 3,000 | 2-fold genome coverage | | Equus caballas (Horse) | 3,000 | 2-fold genome coverage | | Llama sp. (Llama) | 3,000 | 2-fold genome coverage | | Cryptomys sp. (Mole) | 3,000 | 2-fold genome coverage | | Microcebus murinus (Mouse Lemur) | 3,000 | 2-fold genome coverage | | Ochotona sp. (Pika) | 3,000 | 2-fold genome coverage | | Dipodomys sp. (Kangaroo rat) | 3,000 | 2-fold genome coverage | | Tarsier syrichta (Tarsier) | 3,000 | 2-fold genome coverage | | Pongo pygmaeus (Orangutan) | 3,000 | BAC Sequencing | | Macaca mulatta (Macaque) | 3,000 | BAC Sequencing | | Callithrix jacchus (Marmoset) | 3,000 | BAC Sequencing | | Nomascus leucogenys (Gibbon) | 3,000 | BAC Sequencing | | Homo sapiens (Human) | 65,000 | 0.4-fold fosmid-end sequencing of 39 individuals; fully sequence a subset of clones | |
September 2005
At the end of September 2005, the Council approved the following consensus recommendation of priorities for the NHGRI sequencing program:
| Mammalian Genomes | | | | Gallus gallus(Chicken) | 3,000 | Genome refinement | | Rattus norvegicus (Rat) | 3,000 | Genome refinement | | Canis familiaris (Dog) | 3,000 | Genome refinement | | Non-Mammalian Species | |   | | Taeniopygia guttata (Zebra finch) | 1,200 | Full draft genome | | Anolis carolinensis (Anolis lizard) | 2,200 | Full draft genome | | Lutzomiya longipalpis (Sandflies) | 300 | BAC library construction; BAC-end sequencing | | Phlebotomus papatasi (Sandflies) | 170 | BAC library construction; BAC-end sequencing | | Apis mellifera (Honeybee) | 280 | Refinement of draft genome; additional ESTs and 0.2X coverage of Africanized honeybee | | P. h. humanus (Body lice) | 107 | Full draft coverage for one subspecies (Pediculus humanus) | | Human gut microbiome | Varies per organism; total equivalent to ~300 Mb | Sequence draft genomes of 100 bacterial commensals from human gut | |
May 2005
At the end of May 2005, the Council approved the following consensus recommendation of priorities for the NHGRI sequencing program:
| Mammalian Genomes | | | | | Nomascus leucogenys(gibbon) | 3,000 | BAC-end sequencing | 300 | | Microchiroptera sp. (microbat) | 3,000 | 2-fold genome coverage | 6,000 | | Spermophilis tridecemlineatus (squirrel) | 3,000 | 2-fold genome coverage | 6,000 | | Otolemur garnetti (bushbaby) | 3,000 | 2-fold genome coverage | 6,000 | | Choloepus or Bradypus sp. (sloth) | 3,000 | 2-fold genome coverage | 6,000 | | Cynopterus sp. (megabat) | 3,000 | 2-fold genome coverage | 6,000 | | Procavia capensis (hyrax) | 3,000 | 2-fold genome coverage | 6,000 | | Manis sp. (pangolin) | 3,000 | 2-fold genome coverage | 6,000 | | Tupia sp. (tree shrew) | 3,000 | 2-fold genome coverage | 6,000 | | Non-Mammalian Species | |   | | | Anopheles gambiae (mosquito: two molecular forms) | 260 each strain | High-quality draft and assembly | 3,120 | | Heterorhabditis bacterophore (nematode) | 40 | High-quality draft and assembly | 2,400 | | Taeniopygia guttata (zebra finch) | 1,200 | Physical map, BAC-end sequencing, Full sequencing of 50 BAC clones | 50 | |
February 2005
At the beginning of February 2005, NHGRI Council approved the following consensus recommendation of priorities for the NHGRI sequencing program:
| Primate Genomes | | | | | Callithrix jaccus(marmoset) | 3,000 | High-quality draft and assembly | 3,000 | | Non-mammalian Genomes | | | | | Microchiroptera sp. (microbat) | 3,300 | | 3,300 | | Aplysia californica (sea slug) | 1,800 | High-quality draft and assembly | 10,800 | | Rhodnius prolixus (bug; Chagas' vector) | 670 | High-quality draft and assembly | 4,020 | | Acyrthosiphon pisum (Pea aphid) | 300 | High-quality draft and assembly | 1,800 | | Nasonia vitripennis. (hymenopteran wasp) | 350 | High-quality draft and assembly | 2,100 | | Acanthamoeba castellanii (free-living soil amoeba) | 33 | High-quality draft and assembly | 198 | | Schizosaccharomyces octosporus (fission yeast) | 14 | High-quality draft and assembly | 84 | | Batrachochytridium dendrobatidis (chytrid fungus) | 20 | High-quality draft and assembly | 120 | | Schizosaccharomyces japonicus (fission yeast) | 14 | High-quality draft and assembly | 84 | |
NHGRI Council also approved a project to sequence 2,240,000 reads Rat SNPs at 650 bp average read length (1,456 Q20 Mb).
June 2004
At the end of June 2004, the Council approved the following consensus recommendation of priorities for the NHGRI sequencing program:
| Mammalian Genomes | | | | | Dasypus novemcinctus (armadillo) | 3,000 | 2-fold genome coverage | 6,000 | | Cavia porcellus (guinea pig) | 3,000 | 2-fold genome coverage | 6,000 | | Sorex araneus (European Common Shrew) | 3,000 | 2-fold genome coverage | 6,000 | | Loxodonta africana(African Savannah Elephant) | 3,000 | 2-fold genome coverage | 6,000 | | Erinaceus europeaus(European hedgehog) | 3,000 | 2-fold genome coverage | 6,000 | | Felis catus (cat)* | 3,000 | 2-fold genome coverage | 6,000 | | Oryctolagus cuniculis.(rabbit) | 3,000 | 2-fold genome coverage | 6,000 | | Echinops telfairi (tenrec) | 3,000 | 2-fold genome coverage | 6,000 | | Primate Genomes | | | | | Orangutan | 3,000 | High-quality draft and assembly | 18,000 | | Non-mammalian Genomes | | | | | Petromyzon marinus (sea lamprey) | 2,070 | High-quality draft and assembly | 12,420 | | Biomphalaria glabrata (freshwater snail)*** | 950 | High-quality draft and assembly | 5,700 | | Pristionchus pacificus (nematode) | 100 | High-quality draft and assembly | 600 | | Trichinella spiralis (trichinosis vector) | 270 | High-quality draft and assembly | 1,620 | | Hydra magnipapillata (hydra) | 1,300 | High-quality draft and assembly | 7,800 | | Trichoplax adhaerens (placozoan)** | 50 | High-quality draft and assembly | 300 | | Oxytricha trifallax (ciliate) | 60 | High-quality draft and assembly | 360 | | Monosiga ovata (choanoflagellate) | 39 | High-quality draft and assembly | 234 | | Physarum polycephalum (slime mold) | 300 | High-quality draft and assembly | 1,800 | |
*A whitepaper proposal for sequencing the genome of the cat (Felis catus) was submitted for review in October 2002.
Cat White Paper Proposal 
**A whitepaper proposal for sequencing the genome of Trichoplax adhaerens was submitted for review in October 2002.
Trichoplax adhaerens
***A whitepaper proposal for sequencing the genome of Biomphalaria glabrata was submitted for review in October 2003.
Biomphalaria glabrata
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Medical Sequencing Diseasess
| Uncloned, mapped autosomal Mendelian diseases | Demonstration project: Sequence genes in seven intervals implicated in rare Mendelian phenotypes including Lymphedema-Cholestasis Syndrome (LCS), Paroxysmal kinesigenic dyskinesia (PKD), Vitreoretinopathy, neovascular inflammatory (VRNI), aka autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), Joubert syndrome (JBTS1), Dominant restrictive cardiomyopathy, Thoracic aortic aneurysms and dissections (TAAD1), Atrial fibrillation (ATFB3), to identify variants responsible for disease | | X-linked disorders | Sequence all genes on X-chromosome from patient samples with X-linked disorders to identify variants responsible for disease | | Allelic Spectrum of Common Disease | Sequence genes already implicated in common disease in thousands of individuals to understand spectrum of variation and its contribution to common disease | |
