Frontiers in Population Genomics Research Meeting - Meeting Materials

Frontiers in Population Genomics Research Meeting

Meeting Materials

History and Need

• Collins FS, Green ED, Guttmacher AE, Guyer MS; US National Human Genome Research Institute. A vision for the future of genomics research. Nature, Apr 24;422(6934):835-47. 2003. [Full Text ]

Large Cohort Studies

• Willett WC, Blot WJ, Colditz GA, Folsom AR, Henderson BE, Stampfer MJ. Merging and emerging cohorts: not worth the wait. Nature, Jan 18;445(7125):257-8. 2007. [Full Text ]
  
  
• Collins FS, Manolio TA. Merging and emerging cohorts: necessary but not sufficient. Nature, Jan 18;445(7125):259. 2007. [Full Text ]

Building on Genome-Wide Association (GWA) Studies

• Gibson G, Goldstein DB. Human genetics: the hidden text of genome-wide associations. Curr Biol, Nov 6;17(21):R929-32. 2007. [PubMed]

Genomic Technologies Suitable for Population Studies

• ENCODE Project Consortium, Birney E et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, June 14;447(7146):799-816. 2007. [Full Text] ]

Databases

• Mailman MD, Feolo M, Jin Y, et al. The NCBI dbGaP database of genotypes and phenotypes. Nat Genet, Oct;39(10):1181-6. 2007. [Full Text ]

Data Analysis

• Balding DJ. A tutorial on statistical methods for population association studies. Nat Rev Genet, Oct;7(10):781-91. 2006. [Full Text ]
  
  
• Blangero, J. Localization and identification of human quantitative trait loci: King Harvest has surely come. Curr Opin Genet Dev, June (14):233-40. 2004. [PubMed]

Health and Health Disparities of U.S. Race/Ethnic Minority Populations

• Cooper RS, Kaufman JS, Ward R. Race and genomics. N Engl J Med, Mar 20;348(12):1166-70. 2003. [PubMed]

Novel Population Research Approaches

• Roden DM, Altman RB, Benowitz NL, et al., Pharmacogenetics Research Network. Pharmacogenomics: challenges and opportunities. Ann Intern Med, Nov 21;145(10):749-57. 2006. PubMed]
  
  
• Martin GM, Bergman A, Barzilai N. Genetic determinants of human health span and life span: progress and new opportunities. PLoS Genet, Jul 27;3(7):e125. 2007. PubMed]

Clinical Translation

• Nussbaum R. Personalized Genomic Medicine. In: Thompson and Thompson (eds), Genetics in Medicine, pp. 487 and 490-493. 2007. [Full Text ]

OPG Background Materials

• Solicitations from the Office of Population Genomics, 2006-2008
• Timeline and budgets of current OPG activities by fiscal year, FY2006 - FY2011
• Criteria for Supporting New Research Opportunities in Population Genomics, particularly at other NIH Institutes and Centers
• Cohort Studies Summary Table, Studies with > 5,000 subjects
• Characteristics of Genome-wide Association Studies in Complex Disorders and Traits, 2005-2007; Studies Attempting >100,000 SNP Assays

Potentially Useful Links

• Design Considerations for a Potential United States Population-Based Cohort
• Genetic Association Information Network (GAIN) [fnih.org]
• Genes, Environment, and Health Initiative (GEI) [gei.nih.gov]
• PhenX Consensus Measures for Phenotypes and Exposures [phenx.org]
• Database of Genotype and Phenotype (dbGaP) [ncbi.nlm.nih.gov]

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