Gain Analysis Workshop II

Gain Analysis Workshop II

Agenda and Presentations

October 17-18, 2007

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Wednesday, October 17, 2007

7:00 - 8:30 a.m. Continental Breakfast and Registration Lecture Resources 8:30 - 8:45 a.m. Welcome: Introduction and Agenda Francis Collins 8:45 - 9:15 a.m. Overview: Status of GAIN Data available, presentation/publication plans GAIN 2.0 Mental health disorders collaboration Teri Manolio David Wholley Patrick Sullivan 9:15 - 10:30 a.m. GAIN Genotyping Broad genotyping center update Review of genotyping QA pipeline QA process and results to date Stacey Gabriel Finny Kuruvilla Justin Paschall 10:30 a.m. Discussion   10:45 - 11:15 a.m. Break   11:15 - 11:45 a.m. GAIN Genotyping (continued) Groups whose genotypes are completed describe their experience with working through QC issues Ben Neale James Warram Patrick Sullivan 11:45 a.m. - Noon GAIN Datasets Updating and versioning data releases beyond the initial one James Ostell 12:00 - 12:30 p.m. Discussion   12:30 - 1:30 p.m. Lunch     Afternoon Session   1:30 - 2:30 p.m. Imputation IMPUTE Method MACH Method TUNA Method GAIN progress to date Jonathan Marchini Gonçalo Abecasis Dan Nicolae Itsik Pe'er 2:30 - 3:00 p.m. Bayes Factors Meaning and use Comparison to p-values in GAIN Jonathan Marchini 3:00 - 3:30 p.m. Discussion   3:30 - 4:00 p.m. Break   4:00 - 5:00 p.m. Assessing and analyzing copy number variants in GAIN platforms Steve McCarroll 5:00 - 5:45 p.m. Analysis of and adjustment for population structure Paul de Bakker Gilles Thomas 5:45 - 6:00 p.m. Discussion   6:00 p.m. Adjorn   6:30 p.m. Reception

Thursday, October 18, 2007

7:00 - 8:00 a.m. Continental Breakfast   8:00 - 9:00 a.m. GAIN Data Access Experience and Ongoing Issues Brief review of access process, status of distribution, use GAIN human subjects protections: view from external review committees/IOM panel NIH GWAS Policy Emily Harris Wylie Burke Laura Rodríguez 9:00 - 9:15 a.m. Discussion   9:15 - 10:00 a.m. WTCCC Bipolar Disorder Genotype QC filtering Population structure Initial GWA findings, replication Cross-study analyses Follow-up of initial findings Nick Craddock 10:00 - 10:15 a.m. Break   10:15 - 11:00 a.m. FUSION Type II Diabetes Genotype QC filtering Population structure Initial GWA findings, replication Cross-study analyses, including CAD and obesity Follow-up of initial findings Mike Boehnke 11:00 - 11:45 a.m. Prostate Cancer Genotype QC filtering Population structure Initial GWA findings, replication Cross-study analyses, including breast and colon cancer Follow-up of initial findings Matthew Freedman 11:45 a.m. - 12:30 p.m. Breast Cancer Genotype QC filtering Population structure Initial GWA findings, replication Cross-study analyses Follow-up of initial findings Steve Chanock 12:30 - 1:30 p.m. Lunch   1:30 - 2:15 p.m. Crohn's Disease Genotype QC filtering Population structure Initial GWA findings, replication Cross-study analyses Follow-up of initial findings Dan Nicolae 2:15 - 3:00 p.m Panel discussion (all five speakers) Moderator: Francis Collins 3:00 - 3:30 p.m. Conclusion and next steps John Kelsoe Teri Manolio 3:00 - 3:30 p.m. Adjournment Francis Collins