Last updated: April 15, 2015
From Genome Function to Biomedical Insight: ENCODE and Beyond
From Genome Function to Biomedical Insight: ENCODE and Beyond
March 10-11, 2015
Natcher Conference Center
Building 45, Room E1/E2
NIH Campus
Bethesda, Md.
On March 10-11, 2015, the National Human Genome Research Institute (NHGRI) sponsored the workshop - From Genome Function to Biomedical Insight: ENCODE and Beyond - at the Natcher Conference Center on the NIH main campus.
The objectives of the workshop were to:
- Discuss the scientific questions and opportunities for better understanding genome function and applying that knowledge to basic biological questions and disease studies through large-scale genomics studies.
- Consider options for future NHGRI projects that would address these questions and opportunities.
Printable Agenda 
Functional Genomics Workshop Report 
View workshop videos and slides from 
March 10 March 11
Tuesday, March 10, 2015
| Time | Topic | Moderator/Presenter |
|---|---|---|
| 1:00 p.m. | Welcome and Setting the Context
| Eric Green |
| 1:15 p.m. | Purpose of Workshop: Background and Planning Process for Future Initiatives
| Elise Feingold |
| 1:35 p.m. | From Genome Function to Biomedical Insights: Defining the Scientific Challenges
| Ewan Birney |
| 2:05 p.m. | Discussion | |
| 2:30 p.m. | Break | |
| 3:00 p.m. | Genome Function circa 2016: Updates from Related Projects
| Moderator: Daniel Gilchrist |
ENCODE
| Michael Snyder | |
| REMC/IHEC/BLUEPRINT PsychENCODE Genomics of Gene Regulation (GGR) 4D Nucleome FunVar
| Michael Pazin | |
| FANTOM GTEx LINCS TCGA/ICGC KOMP2/IMPC
| Daniel Gilchrist | |
| 4:00 p.m. | Proposals for Future Directions | |
ENCODE PIs' Vision for Functional Genomics
| Joseph Ecker | |
| Recommendations related to genome function from NHGRI's Planning Workshop on the Future Opportunities for Genome Sequencing and Beyond
| Mark Gerstein Richard Myers | |
| 5:00 p.m. | General Discussion
| |
| 6:00 p.m. | Working Dinner | |
| Topic #1: Identifying and Characterizing Functional Elements Moderator: Carol Bult | ||
| 7:00 p.m. | Introduction
| Elise Feingold |
The regulatory landscape: where are the gaps?
| Ross Hardison | |
| 7:30 p.m. | ENCODE 2020: improving the syntax for understanding functional elements in the genome
| Laurie Boyer |
| 7:45 p.m. | Creating a framework for mechanistic studies
| B. Franklin Pugh |
| 8:00 p.m. | Genomics at the "quantum" level: new directions for genomic data generation and functional validation
| William Greenleaf |
| 8:15 p.m. | Topic #1 General Discussion
| |
| 9:00 p.m. | Adjourn | |
Wednesday, March 11, 2014
| Time | Topic | Moderator/Presenter |
|---|---|---|
| Topic #2: Using Genomic Assay of Function to Interpret the Role of Genetic Variation Moderator: Eric Boerwinkle | ||
| 8:00 a.m. | Introduction
| Eric Boerwinkle |
Hirschsprung disease consequent to mutations in the RET gene regulatory network
| Aravinda Chakravarti | |
| 8:25 a.m. | Leveraging whole genome annotation for genotype-phenotype association studies
| Eric Boerwinkle |
| 8:50 a.m. | Genetically predicted endophenotypes: getting to the next level in understanding how genome variation drives disease
| Nancy Cox |
| 9:05 a.m. | Identification of regulatory variation important for maternal metabolism during pregnancy
| William Lowe |
| 9:20 a.m. | Topic #2 General Discussion
| |
| 10:05 a.m. | Break | |
| 10:15 a.m. | Ewan Birney Announcement
| Eric Green |
| Topic #3: Using Genomic Assays of Function to Study Basic Biological Questions Moderator: Aviv Regev | ||
| 10:30 a.m. | Introduction
| Aviv Regev |
Understanding basic biology using functional genomics: solving the genotype-phenotype problem
| Brenda Andrews | |
| 10:50 a.m. | Fundamental insights into gene regulation from genomic analyses: past successes and future challenges
| Karen Adelman |
| 11:10 a.m. | Analyzing cytosine modifications in genomic DNA
| Anjana Rao |
| 11:30 a.m. | Ask not what you can do for ENCODE - ask what ENCODE can do for you
| John O'Shea |
| 11:50 a.m. | Topic #3 General Discussion
| |
| 12:30 p.m. | Lunch | |
| 1:30 p.m. | Discussion
| Moderators: Eric Boerwinkle, Carol Bult, Aviv Regev |
| 2:30 p.m. | Final Recommendations, Including Priorities and Balance of Activities
| Jeff Schloss |
| 3:30 p.m. | Adjourn | |