The Cancer Genome Atlas publishes results for bile duct, uterine and breast cancer

The Molecular Characteristics of Breast Cancer

The TCGA data, more than two petabytes in total from 33 cancer types, catalogs all the key genomic changes - the modifications in DNA, RNA and proteins that cause the uncontrolled cell growth that is the hallmark of malignant tumors.

Last month, two publications from the TCGA network described two diverse types of cancer: uterine cancer and bile duct cancer. The papers demonstrate how using TCGA's dataset can provide a more complete picture of how to prevent, diagnose and treat specific cancer types. The papers also detail the work being done to characterize cancers at a deeper molecular level, as well as demonstrating the power that TCGA holds for cross-cancer comparisons.

Today, the TCGA network published a paper analyzing the molecular characteristics of breast cancer by African and European Ancestry. This paper identifies molecular differences by genetic ancestry, most of which can be captured by known breast cancer subtypes.

Publications and Press

• Bile Duct Cancer Research

  • Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
  • TCGA Investigators Improve Understanding of the Molecular Drivers of Cholangiocarcinoma

• Uterine Cancer Research

  • Integrated Molecular Characterization of Uterine Carcinosarcoma
  • TCGA Study of Rare Uterine Cancer Identifies Molecular Features

• Breast Cancer Research

  • Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas
  • Large data set brings precision to breast cancer diagnosis and care

Additional Resources:

• https://www.genome.gov/17516564/the-cancer-genome-atlas//the-cancer-genome-atlas/
• https://cancergenome.nih.gov/
• https://www.cancer.gov/