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The Secondary Genomics Finding Service (SGFS) can support annotation of up to 2000 exomes/genomes per year on a first-come, first-served basis. The SGFS is open to any Intramural Investigator and can analyze a maximum of 200 samples every 6 months per study or a one-time retrospective analysis of 300 samples.
Please Note: An IRB-approved protocol and/or consent is not required to submit an application to utilize the SGFS. We understand that Investigators may need to amend existing protocols (or incorporate this procedure into planned protocols) to allow for the return of secondary findings to participants. Investigators are encouraged to apply to utilize the SGFS while their protocols are in development or under amendment. Sequence data will not be annotated until the SGFS has been able to review the IRB-approved protocol and consent that applies to your participant population.
Please Note: An IRB-approved protocol and/or consent is not required to submit an application to utilize the SGFS. We understand that Investigators may need to amend existing protocols (or incorporate this procedure into planned protocols) to allow for the return of secondary findings to participants. Investigators are encouraged to apply to utilize the SGFS while their protocols are in development or under amendment. Sequence data will not be annotated until the SGFS has been able to review the IRB-approved protocol and consent that applies to your participant population.
NIH Intramural Working Group on Secondary Findings
Background information on the rationale behind the development and implementation of the SGFS
NIH Intramural Policy for Secondary Findings from Next-Generation Sequencing Research
Darnell et al., 2016
Publication outlining a proposal for a centralized service to facilitate annotation and return of secondary genomic findings as part of the research enterprise
Kalia et al., 2017
Recommendations from the American College of Medical Genetics for the annotation and return of actionable secondary findings in clinical sequencing. Contains the most recent list of genes annotated for secondary findings by the SGFS.
NIH Intramural Working Group on Secondary Findings
Background information on the rationale behind the development and implementation of the SGFS
NIH Intramural Policy for Secondary Findings from Next-Generation Sequencing Research
Darnell et al., 2016
Publication outlining a proposal for a centralized service to facilitate annotation and return of secondary genomic findings as part of the research enterprise
Kalia et al., 2017
Recommendations from the American College of Medical Genetics for the annotation and return of actionable secondary findings in clinical sequencing. Contains the most recent list of genes annotated for secondary findings by the SGFS.
Last updated: March 12, 2020
