Vence L. Bonham Jr., J.D.

Acting Deputy Director

Office Of The Director

Associate Investigator

Social and Behavioral Research Branch

Education

B.A. Michigan State University

J.D. The Ohio State University College of Law

Contact Info

BG 31 RM B1B37G
31 CENTER DR 2070
BETHESDA MD 20892-2070

Biography

Vence L. Bonham, Jr. is acting deputy director of the National Human Genome Research Institute (NHGRI) and a member of the senior leadership team for the institute.

He received his Bachelor of Arts from James Madison College at Michigan State University and his Juris Doctor degree from the Moritz College of Law at Ohio State University. Mr. Bonham was a fellow in the American Association of Medical Colleges Health Services Research Fellowship Program. Mr. Bonham was a tenured faculty member at Michigan State University with appointments in the Colleges of Medicine and Law. He is currently an associate investigator at NHGRI within the Division of Intramural Research's Social and Behavioral Research Branch. Throughout his tenure at NHGRI, he has investigated the integration of new genomic knowledge and precision medicine into clinical settings.

His research focuses primarily on the social implications of new genomic knowledge, particularly in communities that have historically not had access to genomics. The Bonham group also studies sickle cell disease, a condition impacted by emerging curative genomic technologies but its patients have faced significant health disparities both in the United States and globally.

Scientific Summary

Within the Social and Behavioral Research Branch, Mr. Bonham investigates approaches to translating new genomic knowledge and precision medicine into clinical settings. His research program utilizes a variety of methods and data types including qualitative interviews, quantitative survey methods, and biological data including genomic, microbiome, and clinical data.

Mr. Bonham and colleagues have also studied health care professionals’ understanding of genetic variation, using the GKAI scale, which he developed, to measure their knowledge, beliefs, and attitudes about genetic variation. This research examines clinical decision making and explores the clinician-patient relationship.

The Bonham group is also exploring how participation in genomics research impacts certain populations by investigating how genomic research results are returned to participants and the clinical and social implications of these findings.

The Bonham group also studies sickle cell trait and sickle cell disease, a condition that affects 100,000 people in the United States but millions more worldwide. In 2014, Mr. Bonham established the Insights into the Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS), conducted at two U.S. sites and one international site in Sierra Leone. The central goal of this study is to examine the microbial, genomic, psychosocial, and environmental contributors to leg ulcers in sickle cell disease, and more broadly, to evaluate variation in phenotype in the disease. To achieve its goals, the study characterizes the skin microbiome of sickle cell disease patients, collects genomic and clinical data, and uses social science methods to assess the social environment and psychosocial status (e.g., stress, resilience, and depression) of individuals with and without leg ulcers. INSIGHTS is highly interdisciplinary and incorporates national and international expertise from health services research, microbiology, genomics, hematology, psychology and sociology.

The Bonham group has investigated the perspectives of the sickle cell disease community on somatic genome editing. Arising from this body of work is the Democratizing Education for Sickle Cell Disease Gene Therapy, which was launched in 2022 to provide accessible patient education materials globally.

Publications

Vence Bonham Bibliography on PubMed

Bonham V.L. Race and ethnicity disparities in pain treatment. Journal of Law, Medicine and Ethics, 29: 52-68. 2001. [PubMed]

Nerenz D., Bonham V., et al. Eliminating racial/ethnic disparities in health care: Can health plans generate reports? Health Affairs,21(3):259-263. 2002. [PubMed]

Bonham V., Sellers S., Neighbors H.W. John Henryism, and self reported physical health among high SES African-American men. American Journal of Public Health, (5):737-8. 2004. [PubMed]

Bonham V., Warshauer Baker E., Collins F.C. Race and ethnicity in the genomic era: a complexity of the constructs. Am Psychol, 60:9-15. 2005. [PubMed]

Race, Ethnicity, and Genetics Working Group. The Use of Racial, Ethnic, and Ancestral Categories in Human Genetics Research. The American Journal of Human Genetics, 77(4):519-32. 2005. [Full Text]

Todd K.H., Green C., Bonham V.L. Jr., Haywood C. Jr., Ivy E. Sickle cell disease related pain: crisis and conflict. Journal of Pain, 7(7):453-458. 2006. [PubMed]

Phillips EM, Odunlami AO, Bonham VL, Mixed Race: Understanding Difference in the Genome Era. Social Forces, 86(2):795-820. 2007. [PubMed]

Bonham VL, Ramos EM, Unraveling the relative contributions to health differences. CMAJ, 179(7):629-630. 2008. [PubMed]

Bonham VL, Knerr S, Social and Ethical Implications of Genomics, Race, Ethnicity, and Health Inequities. Seminars in Oncology Nursing, 24:254-261. 2008. [PubMed]

Bonham VL, Seller SL, Gallagher TH, Price EG, Frank D, Odunlami AO, Cooper LA, Physicians' attitudes towards race, genetics and clinical medicine. Genetics in Medicine, 11(4):279-86. 2009. [PubMed]

Bonham VL, Citrin T, Modell SM, Franklin TH, Warshauer-Baker E, Fleck LM, Community Based Dialogue: Engaging Communities of Color in the United States' Genetics Policy Conversation. Journal of Health Politics, Policy and Law, 34(3):325-59. 2009. [PubMed]

Bonham VL, Knerr S, Feero WG, Stevens N, Jenkins JF, McBride CM. Patient physical characteristics and primary care physician decision making in preconception genetic screening. Public Health Genomics, 13(6):336-44. 2010. [PubMed]

Frank D, Gallagher TH, Sellers SL, Cooper LA, Price EG, Odunlami AO, Bonham VL. Primary care physicians' attitudes regarding race-based therapies. J Gen Intern Med, 25(5):384-9. 2010. [PubMed]

Knerr S, Ramos E, Nowinski J, Dixon K, Bonham VL. Human difference in the genomic era: Facilitating a socially responsible dialogue. BMC Med Genomics, 3:20. 2010. [PubMed]

Bonham VL, Dover GJ, Brody LC. Screening student athletes for sickle cell trait--a social and clinical experiment. N Engl J Med, 363(11):997-9. 2010. [PubMed]

Knerr S, Wayman D, Bonham VL. Inclusion of racial and ethnic minorities in genetic research: advance the spirit by changing the rules? J Law Med Ethics, 39:502-512. 2011. [PubMed]

Snipes SA, Sellers SL, Tafawa AO, Cooper LA, Fields JC, Bonham VL. Is race medically relevant? A qualitative study of physicians' attitudes about the role of race in treatment decision-making. BMC Health Serv Res, 11:183. 2011. [PubMed]

Goldsmith JC, Bonham VL, Joiner CH, Kato GJ, Noonan AS, Steinberg MH. Framing the research agenda for sickle cell trait: building on the current understanding of clinical events and their potential implications. Am J Hematol, 87(3):340-346. 2012. [PubMed]

Calzone KA, Jenkins J, Culp S, Bonham VL Jr, Badzek L. National nursing workforce survey of nursing attitudes, knowledge and practice in genomics. Per Med, 1:10. 2013. [PubMed]

Hurle B, Citrin T, Jenkins JF, Kaphingst KA, Lamb N, Roseman JE, Bonham VL. What does it mean to be genomically literate: National Human Genome Research Institute meeting report. Genet Med, 15:658-663. 2013. [PubMed]

Cunningham BA, Bonham VL, Sellers SL, Yeh HC, Cooper LA. Physicians' anxiety due to uncertainty and use of race in medical decision making. Medical Care, 52:783-33. 2014. [PubMed]

Bonham VL, Sellers SL, Woolford S. Physicians' knowledge, use, and beliefs about race and genetic variation: New measures and new insight. BMC Health Serv Res, 14:456. 2014. [PubMed]

Bonham VL, Green ED, Pérez-Stable EJ. Examining How Race, Ethnicity, andAncestry Data Are Used in Biomedical Research. JAMA. 320(15):1533-1534, 2018. [PubMed]

Naik RP, Smith-Whitley K, Hassell KL, Umeh NI, de Montalembert M, Sahota P, Haywood C Jr, Jenkins J, Lloyd-Puryear MA, Joiner CH, Bonham VL, Kato GJ. Clinical Outcomes Associated with Sickle Cell Trait: A Systematic Review. Ann Intern Med. 169(9):619-627. 2018. [PubMed]

Persaud A, Desine SA, Blizinsky K, Bonham VL. A CRISPR Focus on Attitudes and Beliefs Towards Somatic Genome Editing from Stakeholders Within the Sickle Cell Disease Community. Genetics in Medicine. doi: 10.1038/s41436-018-0409-6. Epub head of print. 2018. [PubMed]

Selected Book Chapters

Bonham VL, Haywood C, Gamble VN. Sickle cell disease: the past, present and future social and ethical dilemmas. In: The Renaissance of Sickle Cell Disease in the Human Genome Era. United Kingdom: Imperial College Press, p. 311-321. 2007.