Perspectives in Comparative Genomics and Evolution
Event Details
On August 15-16, 2019, the National Human Genome Research Institute (NHGRI), the National Science Foundation (NSF) and the United States Department of Agriculture (USDA) sponsored a meeting Perspectives in Comparative Genomics and Evolution at the Bethesda North Marriott Hotel & Conference Center in Rockville, Maryland.
This meeting's objective was to obtain a big picture look at the current state of the field of comparative genomics with a focus on commonalities across genomic investigations into humans, model organisms (both traditional and non-traditional), agricultural species, wildlife species and microbes.
Outcomes are threefold:
- Identify areas of synergy;
- Identify gaps in knowledge and resources that need attention and development;
- Recommend areas of focus for comparative genomics as a whole, and specifically to NHGRI, with relevance to understanding human health and disease.
What part of this field (if any) belongs with NHGRI and would be at the “forefront” of comparative genomics?
Bethesda North Marriott Hotel & Conference Center
Agenda
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Thursday, August 15, 2019
- 8:45 a.m. - Opening and Meeting Purpose
Jennifer Troyer (NHGRI)
Adele Turzillo (NIFA)
Donal Manahan (NSF) - 8:55 a.m. - Keynote: Comparative Genomics in the Coming Revolution in the Life Sciences
Harris Lewin - Session One: What Is A Reference Genome and What Other Data Types Are Needed?
- 9:35 a.m. - Generating high quality reference genomes for biology
Erich Jarvis - 9:55 a.m. - Comparative epigenomic analysis of regulatory evolution in vertebrate species
Huaijun Zhou - 10:15 a.m. - Plant genome dynamics: challenges and opportunities
Robin Buell - 10:35 - 10:50 a.m. - Break
- 10:50 a.m. Accelerating Drug Discovery by Powering New Model Systems
Carlos Bustamante - 11:10 a.m. Moderated Discussion
Elinore Karlsson / Sofie Salama - 12:00 - 1:00 p.m. Lunch
- Session Two: Integration and Usability of Comparative Genomics Data
- 1:00 p.m. Plant Microbe: harmonizing diverse data sources to promote data interoperability, global-scale analysis, and reuse
Bonnie Hurwitz - 1:20 p.m. Genotype-phenotype data integration across species for disease diagnosis
Melissa Haendel - 1:40 p.m. Decoding the genomic landscape of de novo mutations
Beth Dumont - 2:00 p.m. Moderated Discussion
Lucia Carbone / Adam Arkin - 2:50 - 3:05 p.m. Break
- Session Three: Mechanistic Function, Variation and Phenotype
- 3:05 p.m. The search for regulatory principles governing enhancer function
Emma Farley - 3:25 p.m. Comparative genomics in primates using iPSCs
Yoav Gilad - 3:45 p.m. Natural Variation and Animal Models: Insights into Complexity of Pregnancy Establishment and Loss
Tom Spencer - 4:10 p.m. Leveraging variation in natural systems to disentangle complex phenotypes
Joanna Kelley - 4:30 p.m. Moderated Discussion
Claudio Mello / Charles Danko - 5:15 p.m. Adjourn
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Friday, August 16, 2019
- 8:45 a.m. - NSF and USDA Reimbursement 101
Eric Lyons - 9:00 a.m. - Keynote: How will new data and new tools shape the future of comparative genomics?
Beth Shapiro - Breakout Session 1: Population Genomics
(9:40 - 11:10 am.) - 9:40 a.m. Introduction
María Ávila-Arcos / Clare Gill / Elaine Ostrander / Pam Soltis / Ted Morgan - 9:50 a.m. Disucssion
All - Breakout Session 2: Developmental and Reproduction Genomics
(9:40 - 11:10 am.) - 9:40 a.m. Introduction
John Liu / Nipam Patel / Ollie Ryder / Tom Spencer - 9:50 a.m. Disucssion
All - 11:10 a.m. - 11:25 a.m. Break
- Breakout Session 3: Host/Microbial/Vector Evolution and Interaction
(11:25 am - 12:55 p.m.) - 11:25 a.m. Introduction
Hans Cheng / Elinor Karlsson / Lynn Schirml / Sue VandeWoude - 11:35 a.m. Discussion
All - Breakout Session 4: Systems Biology
(11:25 am - 12:55 p.m.) - 11:25 a.m. Introduction
Charles Danko / Erich Jarvis / Peter Johnson / James Koltes - 11:35 a.m. Discussion
All - 12:55 - 1:55 p.m. Lunch
- 1:55 p.m. Report Back from Breakouts
- 2:15 p.m. NHGRI Strategic Planning
Eric Green - 3:00 p.m. Discussion: Synthesis, Synergies, and Priorities
All - 4:00 p.m. Adjourn
Breakout Note:
The breakout sessions are designed to be an opportunity to discuss areas of overlap in our different communities (medical, agricultural, and wildlife) and think about ways that these communities might increase interactions and synergies to advance this area of science.
Additional Resources
Last updated: January 31, 2020