​Insertion
Definition
Narration
Insertion. Insertion means that a number of nucleotides have been erroneously added to the genome, most often during the process of DNA replication. This number can be as small as a single nucleotide or up to thousands or even millions of nucleotides. The effect of an insertion likewise varies. Some may cause no effect at all, whereas others, even single nucleotide insertions, can completely disrupt the function of a gene and lead to a pathogenic variant associated with a genetic disease.
Leslie G. Biesecker, M.D.
Director & NIH Distinguished Investigator
Center for Precision Health Research
