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Phenotypic Variance

Phenotypic Variance

updated: January 20, 2025

Definition

Phenotypic variance is the observed variability of a particular trait. For many measurable traits (such as height, skin color, and blood pressure) phenotypic variation can be thought of as a distribution. The variation within that distribution centers on an average or mean. Phenotypic variance is often caused by a combination of genetic and environmental factors.

 Phenotypic Variance


Narration

So phenotypic variants can be seen in a disease eye study known as mitochondrial disease within a single family where the same pathogenic variant may be shared, for example, between siblings. Additional genetic and environmental factors can contribute to two phenotypic differences between these individuals.

Peter McGuire
Peter McGuire, M.S., M.B.B.Ch.

Investigator

Metabolic Medicine Branch