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News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… In recent research published online in July in the journal Leukemia, Paul Liu, M.D., Ph.D., asenior investigator and … with a specific kind of relapse-prone acute myeloid leukemia (AML). Though AML is generally thought to be a … American Cancer Society. "We're trying to understand why leukemia patients relapse, and if there are any DNA-level …
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
… Liu's research over the years has been the mechanism of leukemia development at the molecular level, using genetic … a common chromosome abnormality in human acute myeloid leukemia. Using animal models, Dr. Liu has illustrated the importance of CBFB-MYH11 for leukemia development, and how this fusion gene works. His …
Profile
After major advances in hematology, David Bodine retires with an eye towards mentorship and a garden
David Bodine, founder of the Hematopoiesis Section and chief of the Genetics and Molecular Biology Branch, advanced the fields of gene therapy and hematology in his 38 years at the NIH. Now, he plans to continue his contributions to science as an emeritus and through training the next generation of scientists.
… and ask, “Why does that one stem cell go nuts and become leukemia? Is it because of where it is, or is it because of … If you could then change the microenvironment and cure leukemia that way, it'd be a lot better than chemotherapy. … …
News Release
Scientists are exploring the genomic and clinical profiles of people with RUNX1 familial platelet disorder.
… cancers, such as myelodysplastic syndrome, acute myeloid leukemia and acute lymphoblastic leukemia. Many people with this disorder may also have skin … there features that might predict if someone would develop leukemia?” … In the first study, published in the journal …
Clinical Research
A study where both genotypic (individual genetics) and phenotypic (individual disease characteristics) patient data would be analyzed using advanced data-analytics programs to derive meaningful associations for the development of prevention, management and treatment strategies.
… only receive deidentified information. If I develop leukemia and require a bone marrow transplant can I have the … understand what changes occur in patients who progress to leukemia as compared to those who don’t, since it is believed that leukemia is developed from the blood precursor cells in the …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… changes that lead to certain blood cancers, such as leukemia. Although Dr. Liu acknowledged that the zebrafish is not a proven model for leukemia, its transparent embryos develop in the water away …
Staff
Dr. Elisabeth F. Heuston is a molecular biology and bioinformatics Staff Scientist with the Center for Research on Genomics and Global Health (CRGGH).
… mechanisms across multiple subtypes of acute myeloid leukemia. In 2012, Dr. Heuston joined the laboratory of Dr. …
Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute.
… that lead to leukemogenesis, particularly acute myeloid leukemia involving mutations or chromosomal rearrangements of … For studies aimed at understanding the process of leukemia development in patients with chromosomal … t(8:21) identifies patterns of clonal evolution in relapse leukemia . Leukemia 30: 501-504. 2016. Carrington B, Varshney …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… hope to develop new therapies to treat patients with leukemia using their own iPSCs. We encourage other …
For Patients and Families
Genetic research is creating new ways for people to take action and prevent disease and new ways to treat disease through personalized medicine.
… in tumors. Children with a common type of childhood leukemia can be tested to find the right doses of …