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Fact Sheets

A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.

… continue today to conduct large-scale population studies - for example, to determine how often individuals … chips, representing a very large portion of the human genome. Microarrays can also be used to study the extent to … than sequencing, so they may be used for very large studies, as well as for some clinical tests. … To determine …

15 Ways Genomics Influences Our World

Pharmacogenomics

Genomics is helping us choose the right medication at the right dose for each patient.

… for each patient. … Did you know that the sequence of your genome can determine how you respond to certain medications? … or tailoring a person's medications based on their genome, would not be possible without sequencing the genomes … the ClinicalTrials.gov registry and look for ongoing studies with your condition. If you are curious whether any …

Explainer

Use of Population Descriptors in Genomics

Appropriate use of population descriptors in research is a critical scientific issue that is important for advancing genomic science and improving healthcare across human populations.

… we do. Simply stated, the design of some genomic research studies has exacerbated scientific flaws due to how data are … ways in which people can differ from one another. A wide variety of population descriptors are used to describe … to look at the frequency of DNA variants across the genome. The definitions, measurement, uses and …

Policy Issues

How is Genome Editing Used?

Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.

… Genome editing is currently being applied to research on … organisms such as mice or zebrafish. Researchers rely on genome editing tools as a way to explore the connection … help researchers determine if specific changes made to the genome contribute to the disease. It can also lead to the …

The Informed Consent Resource

Required Elements of the Consent Form

Explore the basic elements of informed consent that are required by the Common Rule and that are relevant to genomics.

… to be stored in a research biobank and used for many studies. [OR] We are asking for your participation in a study … will study your entire genetic sequence, known as your genome. The genome sequence will be read and this information will be …

Fact Sheets

Knockout Mice Fact Sheet

A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.

… cannot grow into adult mice. The lack of adult mice limits studies to embryonic development and often makes it more … for studying gene function in a living animal. Such studies will accelerate efforts to translate newfound …

Media Advisory

Annual National DNA Day lecture to honor Congresswoman Louise M. Slaughter

NHGRI memorializes genomics champion Rep. Louise M. Slaughter (D-N.Y.) with an annual National DNA Day lecture named in her honor.

… Kiara Palmer … Media Advisory The National Human Genome Research Institute (NHGRI) will memorialize the life … DNA Day, which celebrates the completion of the Human Genome Project and the anniversary of the discovery of DNA's … interested in participating in genomics research studies. Dr. Noel will be speaking about his experiences in …

Policy Issues

Privacy in Genomics

There are laws and policies that serve to protect the privacy of individuals' genomic information.

… to conduct epidemiological, population-based or other studies on wide-ranging topics such as infectious disease to birth … for genetic information, which can be explored in the Genome Statute and Legislation Database . The Common Rule …

Policies and Guidance

NHGRI-Specific GDS Policy FAQs

Frequently Asked Questions regarding the GDS Policy expectations for NHGRI-funded genomic research.

… to, single nucleotide polymorphism (SNP) array data, genome sequence data, transcriptomic data, epigenomic data, … consistent data sharing expectations across genomics studies. It is important to note that exceptions to the … research use and broad data sharing differ from the NIH-wide expectation? Why does it differ? … How does the NHGRI …

NEWS RELEASE

Cristina Kapustij joins NHGRI as Policy Chief

Cristina Kapustij, M.S., was named chief of the NHGRI's Policy and Program Analysis Branch.

… and Program Analysis Branch (PPAB) at the National Human Genome Research Institute (NHGRI). In her new role, she will … She went on to complete an internship at the American Association for the Advancement of Science, where she … and Medicine; a policy analyst at the Institute for Genome Sciences and Policy at Duke University; and the …