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- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
- Ethical, Legal and Social Implications (ELSI) Research Program6
- Genomics-Enabled Learning Health Systems (gLHS)2
- Genetic Architecture of Complex Traits1
- Genome Technology Program5
- Enhancing Opportunities in Computational Genomics and Data Science1
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Advancing Genomic Medicine Research (AGMR)1
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Clinical Genome (ClinGen) Resource1
- Genomic Innovator Awards2
- Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)2
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
15 Ways Genomics Influences Our World
Advances in genomics are reducing the cost of genome sequencing by a million-fold.
… Advances in genomics are reducing the cost of genome sequencing by a million-fold. … Did you know that your …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… In 2003, an accurate and complete human genome sequence was finished and made available to scientists and researchers two years ahead of the original Human Genome Project schedule and at a cost less than the original estimated budget. … This …
Educational Resources
Shotgun sequencing is a laboratory technique for determining the DNA sequence of an organism's genome.
… Shotgun Sequencing … Shotgun sequencing is a laboratory technique for determining the DNA sequence of an organism's genome. … Deoxyribonucleic Acid (DNA), DNA Sequencing, …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.
… Eric Green, M.D., Ph.D. … As is likely the case for many of your organizations, NHGRI and NIH are starting to bring … announce the completion of a draft sequence of the human genome. The ceremony took place in the East Room of the White … had also accomplished a series of other goals, including sequencing the genomes of a set of model organisms. In fact, …
Talking Glossary
The genome reference sequence provides a general framework and is not the DNA sequence of a single person.
… Human Genome Reference Sequence … The genome reference sequence … provides a general framework and is not the DNA sequence of a single person. … A human genome reference sequence is an accepted representation of the human genome sequence that is used by researchers as a …
The Genomics Landscape
In the April 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the Telomere-to-Telomere (T2T) consortium's publishing of a collection of papers that reported the first truly complete sequence of the human genome.
… The beginning of spring brings some good budgetary news for NIH and NHGRI. … significance of their results.   …  In 2003, the Human Genome Project ended with the generation of an essentially … approach of using the best-available technologies for sequencing DNA and pushing them to their absolute limits. In …
Educational Resources
DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule.
… DNA Sequencing … DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule. … Adenine, … understanding the function of genes and other parts of the genome. There are now several different methods available for …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical building blocks - called "bases" - that … which most DNA sequencing experiments are done. The human genome contains about 3 billion base pairs that spell out the … promote new technologies that could eventually reduce the cost of sequencing a human genome of even higher quality than …
The Genomics Landscape
In the February 12, 2021 edition of The Genomics Landscape, Dr. Eric Green talks about the 20-year anniversary of the publications that reported the draft human genome sequence.
… serve as President Biden’s science advisor and director of the White House Office of Science and Technology Policy … Vision — Generating and analyzing a complete human genome sequence will be routine for any research laboratory, … technologies and the resulting reductions in the cost of DNA sequencing has enabled genome sequencing to …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… Comparative genomics is a field of biological research in which researchers use a variety of tools to compare the complete genome sequences of different species. By carefully comparing … biology of living things have changed over time. As DNA sequencing technology becomes more powerful and less …