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News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… the aggressive, potentially life-threatening tumors from curable, less aggressive tumors. … Researchers with the National Human Genome Research … a specific genomic signature of some aggressive prostate tumors, which may help health care providers pinpoint …
News Release
An ancient, sexually transmitted dog cancer may provide insights into human cancers because of the similarities in the dog and human immune systems.
… unhealthy dog tumor genomes, they found mutations in the tumors' genes that are involved in the ability of the host's … as dangerous outsiders. "The immune systems in dogs with tumors had lost the ability to recognize cancer cells because … it successfully for more than five thousand years." "Most tumors employ strategies to avoid destruction by the immune …
News Release
NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
… around the gene known as ZNF154 that is unique to tumors." Dr. Elnitski is head of the Genomic Functional … identified the methylation mark using DNA taken from solid tumors. "No one in my group slept the night after that … methylation marks in the mixture. Knowing that tumors often shed DNA into the bloodstream, they calculated …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… genomics study of clear cell endometrial cancer (CCEC) tumors to date, National Human Genome Research Institute … also demonstrated that the mutation profiles of CCEC tumors are sometimes similar to other types of uterine … at identifying genes that are mutated (changed) in the tumors of patients with clinically aggressive forms of …
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… of splicing networks across 33 cancer types and 11,000 tumors has demonstrated how mutations disrupt transcriptional … DNA methylation in a variety of gynecological tissues and tumors (from top to bottom, respectively) (Sánchez-Vega et … Related Projects … Laura Elnitski, Ph.D. … Laura Elnitski, tumors, Encyclopedia of DNA Elements (ENCODE), gene …
Staff
Dr. Douglas Stewart is an associate investigator in NHGRI's Center for Precision Health Research.
… increases the risk of various benign and malignant tumors in affected individuals. His research group … among a variety of novel NF1 phenotypes, including glomus tumors, gastrointestinal stromal tumors and pulmonary hypertension. Dr. Stewart's group is …
News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… Jeannine Mjoseth … Cancerous tumors are voracious. Once they have consumed all the oxygen … trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the …
News Release
Receiving a cancer diagnosis can feel like losing control of everything.
… an aggressive tumor - neither of which are ideal. … How tumors differ from each other - either in different organs or … to the patient's specific tumor. A massive new analysis of tumors, published online April 17 in Epigenetics & Chromatin, … ignored among other issues." Researchers have found that tumors with CIMP are linked to different outcomes for …
Profile
Dr. Joan Bailey-Wilson, who retired in September 2022, looks back on her 42-year career as a scientist and reflects on the rapid growth of the genomics field.
… cancer. We identified the first gene to cause carcinoid tumors in one family we studied. What was truly exciting was … the high-risk genetic variant, diagnose and remove their tumors at a very early stage, and thus save their lives.  It … predict individuals at very high risk of carcinoid tumors. As one of the first in her family to go to college, …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… the inhibitor developed significantly fewer metastatic tumors than control mice that had not been treated. Some …