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NHGRI and NICHD program staff will hold a pre-application interactive Q&A webinar for the Developmental Genotype-Tissue Expression Project funding opportunities and answer questions from prospective applicants.
… LDACC and BPC both be engaged together in designing the tissue/sample specific sampling SOP protocols? Yes, the … work with AnVIL ? The LDACC will deposit data from gene expression and genotyping analyses in the AnVIL on a timely … Analysis, and Coordinating Center for the Developmental Genotype-Tissue Expression Project: Jyoti Dayal, M.S. …
News Release
NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.
… this is the first study to use postmortem human brain tissue to investigate ADHD. Other approaches to studying … specific genes are turned on or off, also known as gene expression . They studied two connected brain regions … studies are rare because of the limited donation of brain tissue but are incredibly valuable because they provide …
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
… respectively) that form a dimer for DNA binding and gene expression regulation, are frequent targets of such … Liu PP. Zebrafish homolog of the leukemia gene CBFB : its expression during embryogenesis and its relationship to scl … stem cells generated by non-integrating plasmid expression. Cell Stem Cell, 10:337-44. 2012. [ PubMed ] …
News Release
NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
… of DNA called methylation, which can control the expression of genes like a dimmer on a light switch. … Higher …
News Release
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
… signs of damage. Their metabolism and pattern of gene expression were different from those of healthy cells, … The research team reported that the metabolism and gene expression of the crucial TFH cells are still "largely … transcription factor known as Blimp1. TCF1 turns off expression of Blimp1, just as Blimp1 turns off expression of …
News Release
In a new large-scale genetic analysis, National Institutes of Health (NIH) scientists have found set of small RNA molecules, called microRNAs, in human pancreatic cells that are strongly associated with type 2 diabetes.
… the largest sequenced-based analysis of microRNA expression in human pancreatic islets to date,” said Francis … the stage for understanding how microRNAs fine-tune gene expression in pancreatic islets and its implications for … the largest sequenced-based analysis of microRNA expression in human pancreatic islets to date. The results of …
Staff
Binta Jalloh is a postdoctoral fellow at the Center for Research on Genomics and Global Health (CRGGH).
… Cancer Institute’s Laboratory of Receptor Biology and Gene Expression doing single molecule tracking to understand the … of transcription factors important for regulating gene expression in live budding yeast. Her primary role in the … under Dr. Quinn Vega studying signal transduction and gene expression using bacterial cells. Prior to coming to the USA, …
Research at NHGRI
The Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch studies the genomic and social determinants of complex diseases.
… genomic and social determinants; their effects on gene expression; as well as their contribution to health … cardiovascular disease morbidity and mortality and on gene expression among disproportionately affected subpopulations. …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… modeling studies demonstrated that neuronal-targeted expression of NPC1 rescued neurodegenerative disease, … arrest and senescence, suggesting maintenance of SOX10 expression is important for melanoma progression. These … also evaluate the effects these gene mutants have on other tissue types. Together, these studies will increase …
Staff
Dr. Michael Erdos is an Associate Investigator in the Molecular Genetics Section of the Center for Precision Health Research.
… Network for Systematic Analysis of Pancreatic Islet RNA Expression (InsPIRE) consortium. In addition, he is a … of T2D. Dr. Erdos is the lead scientist in the FUSION tissue biopsy project which aims to investigate tissue … cell state and functional consequence are integrated with genotype and polygenic risk to investigate the functional …