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- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
- Ethical, Legal and Social Implications (ELSI) Research Program6
- Genomics-Enabled Learning Health Systems (gLHS)2
- Genetic Architecture of Complex Traits1
- Genome Technology Program5
- Enhancing Opportunities in Computational Genomics and Data Science1
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Advancing Genomic Medicine Research (AGMR)1
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Clinical Genome (ClinGen) Resource1
- Genomic Innovator Awards2
- Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)2
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
About Genomics
NHGRI considers the ethical, legal and social aspect of genomics research in our work, including these key policy issues
The Genomics Landscape
In the July 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes the inaugural class of the ASHG-NHGRI Genomics and Public Service Fellowship Program.
… Dr. Donohue discusses preserving the history of the Human Genome Project; the importance of conversations about … environments on gene expression noise Hong, et al. Genome Biol. , 2024 May, PMID: 38790076  To function, cells … noise produced at different locations across the genome, this technological innovation could play a crucial …
The Genomics Landscape
In the January 2025 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Erin Ramos as the new director of the Division of Genome Sciences (DGSci).
… a PRS, researchers identify many locations across the genome that have been shown to be associated with a … found that accuracy was related to the regions of the genome involved in that PRS. Certain genomic regions led to … been appointed as the new director of NHGRI’s Division of Genome Sciences (DGSci), part of the institute’s Extramural …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… Techniques to modify DNA in the genome have existed for several decades, but the conversation about the science and ethics of genome editing has grown louder due to faster, cheaper, and … the popular media tends to focus on the potential use of genome editing in humans, the main application of this …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… Genome editing is a method that lets scientists change the … risk. Scientists use different technologies to do this. … Genome editing technologies enable scientists to make changes … add, or replace the DNA where it was cut. The first genome editing technologies were developed in the late 1900s. …
Policy Issues
The Genome Statute and Legislation Database is comprised of state statutes and bills introduced during U.S. state legislative sessions.
… The Genome Statute and Legislation Database is comprised of state … database, together with a description of each topic. The Genome Statute and Legislation Database is reviewed and … for Federal and state laws and regulations. NHGRI’s Genome Statute and Legislation Database does not include …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… Genome editing is currently being applied to research on … organisms such as mice or zebrafish. Researchers rely on genome editing tools as a way to explore the connection … help researchers determine if specific changes made to the genome contribute to the disease. It can also lead to the …
Policy Issues
Most ethical discussions about genome editing center on human germline editing because changes are passed down to future generations.
… Most of the ethical discussions related to genome editing center around human germline because editing … be passed down to future generations. … The debate about genome editing is not a new one but has regained attention … Bioethicists and researchers generally believe that human genome editing for reproductive purposes should not be …
Policy Issues
Patients with genetic disorders and members of the public have diverse about germline genome editing.
… the world, have diverse views about whether germline genome editing should be used to prevent or treat genetic … genetic disorders have diverse views on whether germline genome editing should be used to prevent or treat genetic … condition to be a disability. They worry that if human genome editing becomes widespread, persons born with genetic …
Policy Issues
There are laws and policies that serve to protect the privacy of individuals' genomic information.
… for genetic information, which can be explored in the Genome Statute and Legislation Database . The Common Rule … and Informatics Lab-Space (AnVIL), and The Cancer Genome Atlas  (TCGA). To access sensitive data from one of … could be identified from the requested information. … Genome Statue and Legislative Database Privacy Protections …