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The Genotype-Tissue Expression (GTEx) Project will create a resource that researchers can use to study how inherited changes in genes lead to common diseases
… data release represents the largest atlas of human gene expression and catalog of trait loci to date. … Launched by … of Health (NIH) in September 2010 (See: NIH launches Genotype-Tissue Expression project ), GTEx will create a resource that …
Research Funding
The developmental Genotype-Tissue Expression initiative's goal is to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting.
… Philadelphia, PA University of Maryland Brain and Tissue Bank Baltimore, MD University of Rochester Medical … Education (CORE) Pittsburgh, PA … The human Developmental Genotype-Tissue Expression (dGTEx) project is co-funded by the National Human …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… of genes are expressed as messenger RNA in a particular tissue, and how a cell's regulatory networks control vast … fluorescent labels to complementary DNA (cDNA) from the tissue they are studying. The labeled cDNA binds to its … Human Genome Sequencing, Long-range Planning, Gene Expression, Sequence Variations, Phenotypes, Large-scale …
Research Funding
A scalable and interoperable resource that leverages cloud-based infrastructure for genomic data access, sharing and computing.​
… Trial Not Allowed) … AnVIL Platform Makes Popular NHGRI GTEx Database Free to Download Genomeweb , December 23, 2020 …
AnVIL
The Data Use Oversight System (DUOS) is a semi-automated study registration and DAR management service informed by the GA4GH DUO standard, which enables the secondary use of human genomics and other controlled-access data in compliance with the informed consent of a study’s participants.
… III The NHGRI DAC invited requestors seeking access to the GTEx dataset (phs000424) to submit the same request in DUOS. …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) aims to identify all functional elements in the human and mouse genomes.
… linking DNA elements, chromatin state, and gene expression in 3D U01 HG009395 Alkes Price Soumya Raychaudhuri … of functional genetic variants in RNA processing and expression U01 HG009417 Data Coordination Center J. Michael …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… the RFA, individual projects collect genomic data on gene expression, as well as surrogate markers of regulatory … in different cell fates or cell states. They use the gene expression and functional element data to construct gene … University of Massachusetts Medical School Rules Of Gene Expression Modeled On Human Dendritic Cell Response To …
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… autoimmune diseases affect genome function and gene expression in human germinal centre B cells. They are … affect epigenetic regulatory networks and disrupt gene expression in complex diseases. Xuanyao Liu, University of … lab is to design interpretable AI methods for discovering genotype to phenotype mappings for clinical applications; …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… analyzed because of failed design or failed genotyping. Genotype data were obtained from the remaining 20,000 SNPs in … data set because of the high density of SNP coverage. The genotype data from these regions will be used to determine …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… assessing variant effects in relevant environmental, cell, tissue, and developmental contexts; Aim 2, Systematically … require accurate manipulation of DNA sequences and gene expression as well as interrogation of the functional … reproducible live cell culture and tissue-based experimental genomics disease models. Tissue …