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News Release

NIH completes atlas of human DNA differences that influence gene expression

Researchers funded by NIH have completed a detailed atlas documenting stretches of human DNA that influence gene expression.

… documenting the stretches of human DNA that influence gene expression - a key way in which a person's genome gives rise … scale used by GTEx that enabled researchers to study how gene expression in the liver might be different than in the …

News Release

Genotype-Tissue Expression project expands functional studies of genomic variation

Grants are awarded to GTEx project to explore human gene expression and regulation in different tissues, and how genomic variation modulates that expression.

… has awarded eight grants as part of the Genotype-Tissue Expression (GTEx) project to explore how human genes are … plays in modulating that expression. … An Atlas of Human Gene Expression The GTEx awards will contribute to a resource … inherited spelling changes in the DNA code - may influence gene activity and lead to disease. The grants will add data …

News Release

NIH will expand existing gene expression resources bank to include developmental tissues

NIH will award $38.5 million over five years to the Developmental Genotype-Tissue Expression (dGTEx) project, which aims to build a widely available resource of human developmental gene expression in a multitude of tissues for use in basic and clinical research.

… Zisk … The project will increase our understanding of how gene expression is regulated over time. … Eleven years ago, … of high-quality tissue samples and information on gene expression — important resources that scientists needed …

News Release

NIH researchers unlock pattern of gene activity for ADHD

NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.

… Health (NIH) have successfully identified differences in gene activity in the brains of people with attention deficit … how specific genes are turned on or off, also known as gene expression . They studied two connected brain regions …

News Release

NIH pilot project will match researchers to genes, gene variants of interest

NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.

… and investigate the health consequences of their genes and gene variants. … Reversing a Long-Standing Paradigm To … them to recall genotyped people and examine the genes and gene variants' influence on their phenotypes, an individual's … traits or symptoms and then searching for genes or gene variants that cause or contribute to them. NIH will …

News Release

GTEx findings reveal new insights into how DNA differences influence gene activity

NIH researchers have created a data resource show how differences in an individual's genome can affect gene activity and contribute to disease.

… by the National Institutes of Health Genotype-Tissue Expression (GTEx) project have created a new and … differences in an individual's genomic make-up can affect gene activity and contribute to disease. The new resource … It gives us unique insights into how people differ in gene expression in tissues and organs." NIH launched the GTEx …

News Release

A new role for zebrafish: larger scale gene function studies

A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.

… zebrafish could dramatically accelerate the discovery of gene function and the identification of disease genes in … of Genome Research , the researchers reported that the gene-editing technology known as CRISPR/Cas9 is six times … "It was shown about a year ago that CRISPR can knock out a gene quickly," said Shawn Burgess, Ph.D., a senior …

News Release

NIH grants aim to decipher the language of gene regulation

NIH has awarded grants of more than $28 million aimed at deciphering the language of how and when genes are turned on and off.

… awards emanate from the recently launched Genomics of Gene Regulation (GGR) program of the National Human Genome … disease." With these new grants, researchers will study gene networks and pathways in different systems in the body, … resulting insights into the mechanisms controlling gene expression may ultimately lead to new avenues for developing …

News Release

Gene therapy shows promise for treating Niemann-Pick disease type C1

NIH researchers demonstrated that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1.

… of Health (NIH) researchers have demonstrated in mice that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1 (NPC1). The gene therapy involved inserting a functional copy of the NPC1 …

News Release

NIH researchers tackle thorny side of gene therapy

NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.

… in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare … humans, hoping their findings may eventually help improve gene therapy for humans. Researchers at the National Human … RNA molecules involved in the regulation of gene expression. When the AAV was inserted near Mir341 , the …