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Genetics of type 2 diabetes revealed in unprecedented detail

Type 2 diabetes is a disease that affects ten percent of the world's population, but the genetics underlying the disease remain poorly understood.

… investigation of the underlying genetic architecture of type 2 diabetes has unveiled the most detailed look at the genetic …

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Large-scale genetic analysis shows microRNAs in human pancreas associated with diabetes

In a new large-scale genetic analysis, National Institutes of Health (NIH) scientists have found set of small RNA molecules, called microRNAs, in human pancreatic cells that are strongly associated with type 2 diabetes.

… NIH study identifies new molecules involved in diabetes. … In a new large-scale genetic analysis, scientists … human pancreatic cells that are strongly associated with type 2 diabetes. Researchers discovered the microRNAs in groups of …

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NIH publishes the largest genomic study on type 2 diabetes in sub-Saharan African populations

Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.

… Ph.D. … Researchers show critical association between diabetes and previously unlinked ZRANB3 gene. … National … researchers have reported the largest genomic study of type 2 diabetes (T2D) in sub-Saharan Africans, with data from more …

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Gene therapy shows promise for treating Niemann-Pick disease type C1

NIH researchers demonstrated that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1.

… the single faulty gene that causes Niemann-Pick disease, type C1 (NPC1). The gene therapy involved inserting a … with a faulty NPC1 gene to model Niemann-Pick disease, type C1. The researchers' goal was to correct the faulty NPC1 … therapy shows promise for treating Niemann-Pick disease type C1 … NIH researchers demonstrated that gene therapy may …

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NIH completes in-depth genomic analysis of 33 cancer types

NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.

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NIH researchers identify striking genomic signature shared by five types of cancer

NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.

… as some intermediate and early tumors, depending on the type. Dr. Elnitski's group will also collaborate with … over the course of treatment and to determine if this type of analysis leads to improved detection of a recurrence … Current blood tests are specific to a known tumor type. In other words, clinicians must first find the tumor, …

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NIH grants examine how genomic information can affect patients' health

NIH grants aim to gauge if genomics can be used to help diagnose diabetes, manage heart disease and guide cancer clinicians to the most effective drugs.

… aim to gauge if genomics can be used to help diagnose diabetes, keep heart disease patients out of hospitals and … mistaken for the more common types of diabetes, such as type 1 and type 2 diabetes. These patients often receive inadequate …

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Study identifies novel genomic changes in the most common type of lung cancer

Researchers from The Cancer Genome Atlas Research Network identify novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma.

… main risk factor, adenocarcinoma is also the most common type of lung cancer among lifelong non-smokers and the risk … Study identifies novel genomic changes in the most common type of lung cancer … Researchers from The Cancer Genome …

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NIH researchers unveil new wound-healing role for protein-folding gene in mice

NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.

… bacterial infection from a cut. "A major problem is that diabetes inhibits wound healing," said Dr. Burgess. "The … and may lead to hospitalization or even amputation. Diabetes is the leading causes of non-traumatic lower limb … any wound heal, not just wounds encountered by people with diabetes. Will it reduce scarring and increase the speed of …

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Anti-inflammatory drug halts strokes in children with rare disease

NIH researchers have identified a treatment that significantly decreases the risk of stroke in children with a rare genetic disease called Deficiency of Adenosine Deaminase Type 2 (DADA2).

… disease called DADA2 (deficiency of adenosine deaminase type 2). … The disease results when a malfunctioning gene hampers … genetic disease called Deficiency of Adenosine Deaminase Type 2 (DADA2). … NIH researchers have identified a treatment …