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After major advances in hematology, David Bodine retires with an eye towards mentorship and a garden
David Bodine, founder of the Hematopoiesis Section and chief of the Genetics and Molecular Biology Branch, advanced the fields of gene therapy and hematology in his 38 years at the NIH. Now, he plans to continue his contributions to science as an emeritus and through training the next generation of scientists.
… and ask, “Why does that one stem cell go nuts and become leukemia? Is it because of where it is, or is it because of … If you could then change the microenvironment and cure leukemia that way, it'd be a lot better than chemotherapy. … …
News Release
Scientists are exploring the genomic and clinical profiles of people with RUNX1 familial platelet disorder.
… cancers, such as myelodysplastic syndrome, acute myeloid leukemia and acute lymphoblastic leukemia. Many people with this disorder may also have skin … there features that might predict if someone would develop leukemia?” … In the first study, published in the journal …
The Genomics Landscape
In the October 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes James Thomas as the new director for NIH Intramural Sequencing Center (NISC).
… has been linked to a range of diseases, including leukemia, lymphomas, and other types of cancer, but these …
Clinical Research
A study where both genotypic (individual genetics) and phenotypic (individual disease characteristics) patient data would be analyzed using advanced data-analytics programs to derive meaningful associations for the development of prevention, management and treatment strategies.
… only receive deidentified information. If I develop leukemia and require a bone marrow transplant can I have the … understand what changes occur in patients who progress to leukemia as compared to those who don’t, since it is believed that leukemia is developed from the blood precursor cells in the …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… researchers identify potential drug targets, markers for leukemia risk (2013) Study reveals genomic similarities … Researchers discover key mutation in acute myeloid leukemia (2010) The Cancer Genome Atlas Identifies …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… changes that lead to certain blood cancers, such as leukemia. Although Dr. Liu acknowledged that the zebrafish is not a proven model for leukemia, its transparent embryos develop in the water away …
For Patients and Families
Genetic research is creating new ways for people to take action and prevent disease and new ways to treat disease through personalized medicine.
… in tumors. Children with a common type of childhood leukemia can be tested to find the right doses of …
For Patients and Families
Pharmacogenomics combines the science of how drugs work, called pharmacology, with the science of the human genome, called genomics.
… (Purinethol) to patients with acute lymphoblastic leukemia. Some people have a genetic variant that interferes …
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… non-coding sequence variation associated with pediatric leukemia. We plan to dissect non-coding regulatory elements … genes and describe their function in hematopoiesis and leukemia. Tychele Turner, Washington University in St. Louis …
Staff
Dr. Jennifer Troyer is the director of NHGRI's Division of Extramural Operations.
… Johnson WE, O'Brien SJ. Genetic characterization of feline leukemia virus from Florida panthers. Emerg Infect Dis, …