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- Developmental Genotype-Tissue Expression (dGTEx)1
- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Clinical Genome (ClinGen) Resource1
- Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… genome-editing research. … In light of recent advances in gene-editing research and technologies, the National … decision making for the responsible use of human gene-editing research. This initiative examined the clinical, ethical, legal and social implications of human gene editing. Their efforts included an international summit …
The Genomics Landscape
In the April 2020 edition of The Genomics Landscape, NHGRI Director Eric Green provides an update on the final stage of the Genomics2020 strategic planning process; the NIH website for COVID-19 information, the Gene documentary debut on PBS and more.
… below, the two-part documentary, “Ken Burns Presents The Gene: An Intimate History ,” will debut on PBS stations on … with the new PBS documentary, “Ken Burns Presents The Gene: An Intimate History ,” based on the book by Siddhartha … begins Genomic study points to natural origin of COVID-19 Gene mutation enhances cognitive flexibility in mice, NIH …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… Project covers about 99 percent of the human genome's gene-containing regions, and it has been sequenced to an … 30,000 STSs 52,000 STSs October 1998 DNA Sequence 95% of gene-containing part of human sequence finished to 99.99% … Human Genome Sequencing, Long-range Planning, Gene Expression, Sequence Variations, Phenotypes, Large-scale …
About Genomics
The Human Genome Project was an inward voyage of discovery led by an international team of researchers looking to sequence and map all the genes of our species.
The Genomics Landscape
In the October 1, 2020 edition of The Genomics Landscape, Dr. Eric Green reflects on the last 30 years since the launch of the Human Genome Project.
… 30 years ago. … Researchers from the Genotype-Tissue Expression Project (GTEx) consortium, an NIH Common Fund … a set of studies describing how DNA variation can alter gene expression. The group of papers, published in Science … most comprehensive catalog of genomic variants that affect gene expression produced to date. The studies focus on …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… targets. Although excitement about the potential for gene therapy has grown tremendously since the discovery of … physicians might eventually be able to prescribe targeted gene therapy to make corrections to patient genomes and … reverse disease. … There are two different categories of gene therapies: germline therapy and somatic therapy. …
Policy Issues
Most ethical discussions about genome editing center on human germline editing because changes are passed down to future generations.
… attempted at this time, but that studies that would make gene therapy safe and effective should continue. 1 , 2 Most … in December 2015 with the International Summit on Human Gene Editing in Washington, DC. For more information on this … modify DNA in the genome. Other groups also use the term "gene editing." In general, these terms are used …
Policy Issues
In June 2013, the Supreme Court determined that DNA in its natural form cannot be patented.
… discoveries. Since then, the core of the debate over gene patents has been whether or not the discovery of a gene or sequence of DNA rises to the level of invention … art to which said subject matter pertains." In the case of gene patents, critics have pointed out that such patents fail …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… about 85 percent of their genes! By changing a single gene or multiple genes in a mouse, scientists can observe how … genomic basis of deafness. … Scientists are developing gene therapies - treatments involving genome editing - to … and diabetes. There are two different categories of gene therapies: germline therapy and somatic therapy. …
Policy Issues
Patients with genetic disorders and members of the public have diverse about germline genome editing.
… a survey to understand the public's feelings about gene editing for newborns that would give them a reduced risk … Though they found some enthusiasm among the public about gene editing, they also found that about two-thirds of U.S. … public is about evenly divided on whether they would use gene editing for their own child The public is about evenly …