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NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… the aggressive, potentially life-threatening tumors from curable, less aggressive tumors. … Researchers with the National Human Genome Research … a specific genomic signature of some aggressive prostate tumors, which may help health care providers pinpoint …
News Release
NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.
… set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer. … More than 10,000 Tumors Analyzed "This project is the culmination of more than … with unprecedented understanding of how, where and why tumors arise in humans, enabling better informed clinical …
News Release
An ancient, sexually transmitted dog cancer may provide insights into human cancers because of the similarities in the dog and human immune systems.
… unhealthy dog tumor genomes, they found mutations in the tumors' genes that are involved in the ability of the host's … as dangerous outsiders. "The immune systems in dogs with tumors had lost the ability to recognize cancer cells because … it successfully for more than five thousand years." "Most tumors employ strategies to avoid destruction by the immune …
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TCGA researchers have found that chromophobe renal cell carcinoma stems partly from gene alterations in the mitochondria, the cell's energy supplier.
… examining the entire genomes of 50 of the 66 ChRCC tumors studied, a high number for a rare cancer. The study … DNA. This led researchers to discover that ChRCC tumors favor a different energy-generating process than that … in the mitochondria, the cell's energy supplier. … Kidney tumors, chromophobe renal cell carcinoma, ChRCC, The Cancer …
News Release
NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
… around the gene known as ZNF154 that is unique to tumors." Dr. Elnitski is head of the Genomic Functional … identified the methylation mark using DNA taken from solid tumors. "No one in my group slept the night after that … methylation marks in the mixture. Knowing that tumors often shed DNA into the bloodstream, they calculated …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… the most common type of brain tumor in adults, but these tumors are difficult to treat. The research team noticed that … folded, causing genetic neighborhoods to merge. Within the tumors that have a mutated IDH gene, scientists found that …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… genomics study of clear cell endometrial cancer (CCEC) tumors to date, National Human Genome Research Institute … also demonstrated that the mutation profiles of CCEC tumors are sometimes similar to other types of uterine … at identifying genes that are mutated (changed) in the tumors of patients with clinically aggressive forms of …
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… of splicing networks across 33 cancer types and 11,000 tumors has demonstrated how mutations disrupt transcriptional … DNA methylation in a variety of gynecological tissues and tumors (from top to bottom, respectively) (Sánchez-Vega et … Related Projects … Laura Elnitski, Ph.D. … Laura Elnitski, tumors, Encyclopedia of DNA Elements (ENCODE), gene …
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The Cancer Genome Atlas identified molecular subtypes to help clinicians determine which tumors are more aggressive and which will respond to treatment.
… subtypes that will help clinicians determine which tumors are more aggressive and which are more likely to … in the two PTC types, allowing them to characterize tumors and determine both the pathway a tumor uses to send … therapies. The study also showed that BRAF -driven tumors have a broader range of genetic complexity than …
News Release
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas Network have found.
… to explore therapies in defined sets of patients whose tumors have specific genomic abnormalities. Stomach cancers … complex statistical analyses of molecular data from 295 tumors. They used six molecular analysis platforms including … DNA sequencing, RNA sequencing, and protein arrays. Tumors in the first group, which represented 9 percent of the …