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- Developmental Genotype-Tissue Expression (dGTEx)1
- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Clinical Genome (ClinGen) Resource1
- Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
News Release
NHGRI is awarding Genomic Innovator Awards to nine institutions to support the research of 12 early career scientists in the field of genomics. The awards will total up to $27 million over five years.
… Stanford, California Apply CRISPR tools to understand gene regulation related to common, complex diseases.  Audrey … medicine, CRISPR, non-coding DNA and RNA sequences, gene regulation, single-cell biology, chromatin state …
Research Funding
The primary mission of the Alliance of Genome Resources (the Alliance) is to develop and maintain sustainable genome information resources that facilitate the use of diverse model organisms in understanding the genetic and genomic basis of human biology, health and disease. This understanding is fundamental for advancing genome biology research and for translating human genome data into clinical utility.
… (Alliance), Model Organism Databases (MODs), and the Gene Ontology (GO) Consortium is to develop and maintain … into clinical utility. … The Model Organism Databases and Gene Ontology (GO) Consortium resources serve as well-curated … and variants, human disease associations, pathways, gene expression, and both protein–protein and genetic …
The Genomics Landscape
In the July 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes the inaugural class of the ASHG-NHGRI Genomics and Public Service Fellowship Program.
… best,  … Effect of genomic and cellular environments on gene expression noise Hong, et al. Genome Biol. , 2024 May, PMID: … proteins. One of the first steps of this process, called gene expression, involves copying DNA into RNA. While this is …
The Genomics Landscape
In the January 2024 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Dr. Adam Phillippy as the founding director of the Center for Genomics and Data Science Research (CGDSR).
… Food and Drug Administration (FDA), which approved two gene therapies for the treatment of sickle cell disease. … region of the angiotensin-converting enzyme 2 (ACE2) gene, which encodes the cellular receptor for SARS-CoV-2. In the edited mice, expression patterns of ACE2 were similar to those in humans …
The Genomics Landscape
In the November 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, celebrates the 30th anniversary of the NHGRI Intramural Research Program as well as announces the launch of a new digital history archive.
… regulatory changes in cis and trans and the evolution of gene expression in humans and chimpanzees Barr et al. Genome Biol … how he came to discover the disorder and its associated gene by genome sequencing. A study participant with VEXAS …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… from those in people. Building on years of mouse and gene regulation studies, they have developed a resource that … that, in general, the systems that are used to control gene activity have many similarities in mice and humans, and … However, they also uncovered many DNA variations and gene expression patterns that are not shared, potentially limiting …
The Genomics Landscape
In the February 3, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the December 2021 NHGRI symposium's success in confronting the difficult pasts of eugenics and scientific racism.
… @NHGRI_Director .  All the best,  … The Genotype-Tissue Expression (GTEx) project generated NHGRI’s most frequently … studying the relationship between genomic variation and gene expression. Because GTEx data can be shared for general … genomics research. … Genomics Research Silencing a faulty gene may uncover clues to rare forms of ALS For skin …
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… Duke University High-throughput functional annotation of gene regulatory elements and variants critical to complex … resource of functional elements, TF footprints and gene regulatory interactions HG011986 Ansuman Satpathy … autoimmune diseases affect genome function and gene expression in human germinal centre B cells. They are …
The Genomics Landscape
In the September 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, recaps the April 2023 virtual reunion of the leaders of the five genome-sequencing centers (G5), where they tell the untold story on how they ushered the Human Genome Project across the finish line in 2003.
… disease.  All the best,  … Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant … with HCFP1. These variants regulate the activity of a gene called GATA2, a gene known to be important for brain stem development. These …
Media Availability
The Cancer Genome Atlas identified molecular subtypes to help clinicians determine which tumors are more aggressive and which will respond to treatment.
… The researchers developed a scoring system to reflect gene expression in the two PTC types, allowing them to …