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- Ethical, Legal and Social Implications (ELSI) Research Program6
- Genomics-Enabled Learning Health Systems (gLHS)2
- Genetic Architecture of Complex Traits1
- Genome Technology Program5
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Genomic Innovator Awards2
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)3
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. Editing DNA can lead to changes in physical … risk. Scientists use different technologies to do this. … Genome editing technologies enable scientists to make changes …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… Techniques to modify DNA in the genome have existed for several decades, but the conversation about the science and ethics of genome editing has grown louder due to faster, cheaper, and more …
Policy Issues
Most ethical discussions about genome editing center on human germline editing because changes are passed down to future generations.
… Most of the ethical discussions related to genome editing center around human germline because editing changes … has the potential to make such editing more accurate and even "easy" in comparison to older technologies. …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas. … Basic research exploring … organisms such as mice or zebrafish. Researchers rely on genome editing tools as a way to explore the connection …
Policy Issues
Patients with genetic disorders and members of the public have diverse about germline genome editing.
… Patients with genetic disorders and members of the public, both in the United States and … the world, have diverse views about whether germline genome editing should be used to prevent or treat genetic disorders. …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… In the United States and around the world, scientific institutions are developing … decision-making for the responsible use of human genome-editing research. … In light of recent advances in …
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… 2014 highlights research on the use of DNA biorepositories and electronic medical records (EMRs) to better understand … Network. eMERGE is supported by the National Human Genome Research Institute (NHGRI), part of the National … traits, conditions and diseases. They examine the genome in many different ways, and include large patient data …
15 Ways Genomics Influences Our World
Genomics is altering a genome with unparalleled efficiency and precision.
… Genomics is altering a genome with unparalleled efficiency and precision. … Did you know that in the 15 years since we … time, we have developed powerful new technologies for editing  a human (or any) genomes? We may not yet have jet …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
… Ph.D. … NHGRI researchers work with patients, families and the scientific community to improve the informed consent … … As public interest and expanded research in human genome editing grows, many questions remain about ethical, legal and …
Research Funding
The E​MERGE Network develops, disseminates and applies approaches to research that combine biorepositories with electronic medical record systems.​
… Current Network Participants  … Workgroups and Missions  Working Group Co-Chairs Goals Comprehensive … on understanding how best to validate and implement genome informed risk assessments, which are defined as a … developing disease. The Network is investigating whether genome informed risk assessments for select conditions can be …