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Dr. Meru Sadhu is the head of the Systems Biology and Genome Engineering Section at the National Human Genome Research Institute. ​
… in parallel. These strategies leverage the strengths of CRISPR technologies, large-scale oligonucleotide synthesis, … SM, Sadhu MJ. Comprehensive deletion scan of anti-CRISPR AcrIIA4 reveals essential and dispensable domains for … L. Highly parallel genome variant engineering with CRISPR-Cas9 . Nat Genet . 50(4):510-514. 2018. Forsberg SK, …
Policy Issues
Patients with genetic disorders and members of the public have diverse about germline genome editing.
… "compelling medical applications justifying the use of CRISPR/Cas9 in embryos." 3 In July 2017, using non-federal … Huang and Sun Yat-sen of University in Guangzhou used CRISPR on nonviable embryos from local fertility clinics in … Editing, Gene Therapy, Genetic Disorder, Genetic Disease, CRISPR-Cas9, CRISPR … Patients with genetic disorders and …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… reported that the gene-editing technology known as CRISPR/Cas9 is six times more effective than other techniques … specific sequences. The study also demonstrated that the CRISPR/Cas9 method can be used in a "multiplexed" fashion - … their functions. "It was shown about a year ago that CRISPR can knock out a gene quickly," said Shawn Burgess, …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… the base-editing method in 2016, funded in part by NHGRI. "CRISPR editing, while revolutionary, cannot yet make precise … correct accelerating aging disorder. … DNA-editing, CRISPR, progeria, Hutchinson-Gilford progeria syndrome, base …
Social Media
NHGRI launched a Reddit Science "Ask Me Anything" series to share our genomics expertise with the public through online question and answer sessions.
… and answer sessions. ​ … Reddit, Ask Me Anything, AMA, CRISPR, Genetic Testing … NHGRI launched a Reddit Science …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… includes maintaining an updated guide for protocols using CRISPR/Cas9 and other gene-editing tools. This guide is … more recently gene editing using site-specific nucleases (CRISPR/Cas9). The core breeds, in-house, 90 percent of the … … Lisa Garrett, genetically engineered mice, gene editing, CRISPR/Cas9, transgenic mice … Lisa Garrett is an associate …
Jobs at NHGRI
NHGRI is seeking a postdoc to join the Systems Biology and Genome Engineering Section in Bethesda, Maryland.
… methods. This includes harnessing the strengths of CRISPR, large scale oligo synthesis, and yeast genetics. … and Genome Engineering Section, in Bethesda, Maryland.​ … CRISPR, Large Scale Oligo Synthesis, Yeast Genetics, …
Policy Issues
Most ethical discussions about genome editing center on human germline editing because changes are passed down to future generations.
… but has regained attention following the discovery that CRISPR has the potential to make such editing more accurate … ​ … Genome Editing, Gene Editing, Gene Therapy, CRISPR, Human Gremline Editing, DNA Editing … Most ethical …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… perpetual germ cell production. The researchers used the CRISPR-Cas9 gene-editing technique to remove Tfap2 from … adult stem cells, whole-genome sequence data, CRISPR-Cas9, gene-editing … In a study published in the …
15 Ways Genomics Influences Our World
Genomics is altering a genome with unparalleled efficiency and precision.
… them fluorescent. But in 2012, a new technique called CRISPR  was developed and has revolutionized genome editing. The scientists who developed CRISPR recognized that they could borrow tools from the … scissors" for surgically editing any DNA in any organism. CRISPR has made genome editing much simpler, faster, cheaper, …