Search Results
Research Funding
The Genomic Variation Program supports large-scale studies of human genetic variation.
… About 99.5 percent of a person's DNA is the same as any unrelated person's DNA. Differences in … explains some of the differences among people, such as eye color and blood group, as well as whether a person has a higher or …
Fact Sheet
Genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases.
…  Genomic variation reflects the differences in a person’s DNA compared to other peoples’ DNA.  There are multiple … subset of genomic variants contributes to human health and disease.  Researchers create reference human genome … variants influence physical characteristics, like eye color and height; others influence health conditions or how a …
News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… are voracious. Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells … about how the body signals the lack of oxygen in melanoma skin cancer, National Institutes of Health (NIH) researchers … rays from the sun and from tanning beds can damage the DNA in skin cells, causing melanoma. If melanoma is caught …
News Release
Grants are awarded to GTEx project to explore human gene expression and regulation in different tissues, and how genomic variation modulates that expression.
… (GTEx) project to explore how human genes are expressed and regulated in different tissues, and the role that genomic … genomic variants - inherited spelling changes in the DNA code - may influence gene activity and lead to disease. … genome regions of more than 15 tissue types and look for variations in DNA sequences and structures. Proteins are the …
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… Berlin Massively parallel characterization of variants and elements impacting transcriptional regulation in dynamic … Stanford University Stanford Center for Connecting DNA Variants to Function and Phenotype HG011972 Marc Vidal … Nature Perspective, September 4, 2024  Differences in our DNA have major influences on how our genomes function, but …
Educational Resources
DNA replication is the process by which a molecule of DNA is duplicated.
… DNA Replication … DNA replication is the process by which a molecule of DNA is duplicated. … DNA, Cell Division, Cell Biology … DNA replication is the …
Educational Resources
DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule.
… DNA Sequencing … DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule. … Adenine, Cytosine, Guanine, … to by the first letters of their chemical names: A, T, C, and G) encodes the biological information that cells use to …
The Genomics Landscape
In the September 3, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about the Impact of Genomic Variation on Function (IGVF) Consortium, the 2020 Genomic Innovator Awards and more.
… Last month, Dr. Sara Hull (NHGRI Bioethics Core Director) and I answered questions about bioethics and genomics … National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) . Dr. Criswell is a rheumatologist with … 3D genome NIH-supported scientists demonstrate how genetic variations cause eczema Small set of genes may provide unique …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
… … Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical … building blocks - called "bases" - that make up the DNA molecule. … Sequencing DNA means determining the order of … to determine which stretches of DNA contain genes and which stretches carry regulatory instructions, turning …