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Staff
Dr. Sharon Milgram is an adjunct investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute.
… and protein trafficking in polarized cells, including kidney and airway epithelial cells. Epithelial cells form a … other epithelial cells and model systems, including the kidney and gastrointestinal tract. Her laboratory's findings …
Research at NHGRI
CRGGH uses genomic tools to understand the pathobiology of metabolic disorders, including obesity, hypertension, diabetes, dyslipidemia, and kidney disease.
… obesity, hypertension, diabetes, dyslipidemia, and kidney diseases, in different human populations with … obesity, hypertension, diabetes, dyslipidemia, and kidney disease. … CRGGH uses genomic tools to understand the … obesity, hypertension, diabetes, dyslipidemia, and kidney disease. … Research at NHGRI …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… genomics study of clear cell endometrial cancer (CCEC) tumors to date, National Human Genome Research Institute … also demonstrated that the mutation profiles of CCEC tumors are sometimes similar to other types of uterine … at identifying genes that are mutated (changed) in the tumors of patients with clinically aggressive forms of …
News Release
NIH researchers have developed a breath test that measures how well patients with methylmalonic acidemia (MMA) respond to receiving liver or combined liver and kidney transplantation.
… (MMA) respond to receiving liver or combined liver and kidney transplantation. Researchers also used the test to … from the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Mental Health. … causes toxic substances to build up, which may result in kidney disease, pancreatitis, movement disorders, …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… DNA methylation in a variety of gynecological tissues and tumors (from top to bottom, respectively) (Sánchez-Vega et … whose epigenetic state is commonly altered in epithelial tumors from 15 distinct types of cancer, providing a … she is pursuing the role of the methylator phenotype in tumors, characterized by extensive methylation of the tumor …
Media Availability
The Cancer Genome Atlas identified molecular subtypes to help clinicians determine which tumors are more aggressive and which will respond to treatment.
… subtypes that will help clinicians determine which tumors are more aggressive and which are more likely to … in the two PTC types, allowing them to characterize tumors and determine both the pathway a tumor uses to send … therapies. The study also showed that BRAF -driven tumors have a broader range of genetic complexity than …
Staff
Dr. Suzanne Hart was the deputy director of the Medical Genetics and Genomic Medicine Fellowship Training Program until she retired in late 2023.
… genetic diseases of the teeth, the oral cavity and the kidney. … Dr. Hart uses molecular and biochemical techniques … understand genetic diseases of the teeth, oral cavity and kidney. Gum tissue is important in tooth development, with … teeth by age 20. Dr. Hart also studies medullary cystic kidney disease (MCKD), an inherited disorder associated with …
Educational Resources
A carcinogen is an agent with the capacity to cause cancer in humans.