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Research Funding
The developmental Genotype-Tissue Expression initiative's goal is to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting.
… The human Developmental Genotype-Tissue Expression (dGTEx) project is co-funded by the National Human … as well as a tissue bank to study the regulation of gene expression in multiple relatively healthy reference neonatal, … - 2019), which investigated how genetic variation impacts gene expression in multiple tissues across individuals. The …
Educational Resources
The gene is the basic physical unit of inheritance.
… Gene … The gene is the basic physical unit of inheritance. … Inheritance, Gene, Double Helix, DNA, DNA Sequence … The gene is considered the basic unit of inheritance. Genes are … The gene is the basic physical unit of inheritance. …
Educational Resources
A candidate gene is a gene whose chromosomal location is associated with a particular disease or other phenotype.
… Candidate Gene … A candidate gene is a gene whose chromosomal location is associated with a … The term candidate gene refers to a gene that is believed to be related to a particular trait, … A candidate gene is a gene whose chromosomal location is associated with a …
News Release
NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.
… Health (NIH) have successfully identified differences in gene activity in the brains of people with attention deficit … how specific genes are turned on or off, also known as gene expression . They studied two connected brain regions … NIH researchers unlock pattern of gene activity for ADHD …
News Release
NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.
… and investigate the health consequences of their genes and gene variants. … them to recall genotyped people and examine the genes and gene variants' influence on their phenotypes, an individual's … traits or symptoms and then searching for genes or gene variants that cause or contribute to them. NIH will …
Educational Resources
A gene pool is the total genetic diversity found within a population or a species.
… Gene Pool … A gene pool is the total genetic diversity found within a … A gene pool refers to the combination of all the genes … present in a reproducing population or species. A large gene pool has extensive genomic diversity and is better able … challenges. Inbreeding contributes to a smaller gene pool, making populations or species less able to adapt …
Educational Resources
Gene mapping is the process of establishing the locations of genes on the chromosomes.
… Gene Mapping … Gene mapping is the process of establishing the locations of … Gene mapping refers to the process of determining the … on chromosomes. Today, the most efficient approach for gene mapping involves sequencing a genome and then using … Gene mapping is the process of establishing the locations of …
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
… Gene Amplification … Gene amplification is an increase in the number of copies of a gene sequence. … Gene amplification refers to an increase in the number of copies of a gene in a genome. Cancer cells, for example, sometimes … Gene amplification is an increase in the number of copies of …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… of Cardiovascular Disease in Africans Americans Study (GENE-FORECAST®) study is developing a community-based cohort … GENE-FORECAST® will test the working hypothesis that … of these putative functional DNA variants of interest. GENE-FORECAST® Study Flyer … African-Americans. For potential participants meeting the GENE-FORECAST® eligibility criteria, the risks and benefits …
Educational Resources
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… Tumor Suppressor Gene … A tumor suppressor gene directs the production of a protein that is part of the … BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … A tumor suppressor gene encodes a protein that acts to regulate cell division, keeping it in check. When a tumor suppressor gene is inactivated by a mutation, the protein it encodes is …