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News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… controlling movement. Midbrain neurons from the new mouse model. The green shows the clumped alpha-synuclein. Image … In the study, the authors used a Parkinson's disease mouse model that carried extra copies of a mutated form of … about the cross-bred mice. Ultimately, this mouse model can be used to develop and evaluate new treatments for …
Staff
Valentina Di Francesco is NHGRI's Chief Data Science Strategist and Director of the Office of Genomic Data Science within the NHGRI Office of the Director.
… opportunities, and oversaw a grant portfolio that included model organism databases, and the NHGRI Genomic Data Science … data science, computational genomics, bioinformatics, model organism databases … Valentina Di Francesco is NHGRI's …
Research Funding
The primary mission of the Alliance of Genome Resources (the Alliance) is to develop and maintain sustainable genome information resources that facilitate the use of diverse model organisms in understanding the genetic and genomic basis of human biology, health and disease. This understanding is fundamental for advancing genome biology research and for translating human genome data into clinical utility.
… mission of the Alliance of Genome Resources (Alliance), Model Organism Databases (MODs), and the Gene Ontology (GO) … information resources that facilitate the use of diverse model organisms in understanding the genetic and genomic basis of …
Event
A joint NHGRI-NCATS hosted meeting bringing together researchers, clinicians, families and patient advocates from around the world to discuss the natural history, disease pathophysiology, genetics and treatments for rare inborn metabolic errors.
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… expression after initial and repeat dosing in a mouse model of methylmalonic acidemia . Mol Ther Methods Clin Dev . … expressing human methylmalonyl-CoA mutase in a murine model of methylmalonic acidemia (MMA) . Mol Genet Metab. … serotype 8 gene transfer rescues a neonatal lethal murine model of propionic acidemia . Hum Gene Ther . 2011. Chandler …
Organization
NHGRI is the driving force for advancing genomics research at the National Institutes of Health, the world's largest biomedical research agency.
Policies and Guidance
This page provides an overview of Resource Sharing Plans, a required document in most NIH funding applications. Most applicants for NIH funding must provide a Resource Sharing Plan (RSP) documenting plans for sharing resources that result from their federally funded work. NIH Policies that govern the sharing of resources include the NIH Model Organism Sharing Policy and the NIH Research Tools Policy.
… resources  NHGRI encourages investigators to disseminate model organisms and research tools via a stable, public repository … that govern the sharing of resources include the NIH Model Organism Sharing Policy and the NIH Research Tools …
About Genomics
An interactive timeline listing key moments from the history of the project.
… letters; mapping and sequencing the genomes of other organisms important to the study of biology; and developing … James Watson, Francis Collins, Human Genome Sequence, Model Organisms, Large-scale Sequencing Centers, Protein-coding …
News Release
NIH recently awarded approximately $6.8 million in grants to several research teams to study the biology of rare and undiagnosed diseases.
… funding establishes two new research centers, including a Model Organisms Screening Center and a Metabolomics Core, as part … the country, in addition to two DNA sequencing centers, a Model Organisms Screening Center, a Metabolomics Core, a …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… Populations In Inflammation In vivo inflammation model, mouse T helper cells Jeremy Luban, M.D. and Manuel …