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News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… genomics study of clear cell endometrial cancer (CCEC) tumors to date, National Human Genome Research Institute … also demonstrated that the mutation profiles of CCEC tumors are sometimes similar to other types of uterine … at identifying genes that are mutated (changed) in the tumors of patients with clinically aggressive forms of …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… DNA methylation in a variety of gynecological tissues and tumors (from top to bottom, respectively) (Sánchez-Vega et … whose epigenetic state is commonly altered in epithelial tumors from 15 distinct types of cancer, providing a … she is pursuing the role of the methylator phenotype in tumors, characterized by extensive methylation of the tumor …
Media Availability
The Cancer Genome Atlas identified molecular subtypes to help clinicians determine which tumors are more aggressive and which will respond to treatment.
… subtypes that will help clinicians determine which tumors are more aggressive and which are more likely to … in the two PTC types, allowing them to characterize tumors and determine both the pathway a tumor uses to send … therapies. The study also showed that BRAF -driven tumors have a broader range of genetic complexity than …
Educational Resources
A carcinogen is an agent with the capacity to cause cancer in humans.
News Release
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas Network have found.
… to explore therapies in defined sets of patients whose tumors have specific genomic abnormalities. Stomach cancers … complex statistical analyses of molecular data from 295 tumors. They used six molecular analysis platforms including … DNA sequencing, RNA sequencing, and protein arrays. Tumors in the first group, which represented 9 percent of the …
Educational Resources
An oncogene is a mutated gene that contributes to the development of a cancer.
Staff
Dr. Douglas Stewart is an associate investigator in NHGRI's Center for Precision Health Research.
… increases the risk of various benign and malignant tumors in affected individuals. His research group … among a variety of novel NF1 phenotypes, including glomus tumors, gastrointestinal stromal tumors and pulmonary hypertension. Dr. Stewart's group is …
Educational Resources
Cancer is a group of diseases characterized by uncontrolled cell growth.