Search Results
Facet (Page)
Refine Your Search
Audiences
Content Formats
Events
Sections
Divisions
Programs
- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
News Release
NIH-led study finds genetic markers that explain up to 12% of the differences between two people’s blood pressure.
… explain up to 12% of the differences between two people’s blood pressure. … National Institutes of Health researchers … as genomic loci , that appear to influence a person’s blood pressure. Results of the study also point to several … Genetics , is one of the largest such genomic studies of blood pressure to date, including data from over 1 million …
Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
… of the different cell types found in the body. When stem cells divide, they can form more stem cells or other cells that perform specialized functions. Embryonic stem …
News Release
On June 26, 2000, nearly 10 years into the 13-year project, President Bill Clinton announced an important milestone for the Human Genome Project at a major White House ceremony.
… Clinton announced an important milestone for the HGP at a White House ceremony, which included comments from U.K. Prime … of the HGP and NHGRI communities were invited to the White House to attend the ceremony. All have lifelong … Research Program, remembered standing outside of the White House's fence before the ceremony. "No one got in …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… the origin of the mutation that causes sickling of red blood cells, which reduces their ability to carry oxygen and can … the origin of the mutation that causes "sickling" of red blood cells. ​ … Sickle allele, Sickle cell disease, Center …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… its make-up is different among cell types, even among cells that are similar. Investigators from two National Human … creating maps of what chromatin looks like in individual cells. They've combined several technologies, including DNA … have gained insights into how genomic information inside cells is controlled - literally turned on or off. The study …
Fact Sheet
A variety of approaches target the blood stem cells to relieve or reduce your symptoms of sickle cell disease.
… the severity of the disease. Learn more about your red blood cells to help you better understand these various approaches. … … Types of treatments A variety of approaches target the blood stem cells to reduce your symptoms of sickle cell …
Genetic Disorders
Factor V Leiden thrombophilia is an inherited disorder of blood clotting.
… Factor V Leiden thrombophilia is an inherited disorder of blood clotting. … Factor V Leiden is the name of a specific … thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels. People who have the factor V … thrombophilia. Between 3 and 8 percent of the Caucasian (white) U.S. and European populations carry one copy of the …
News Release
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
… But its presence is necessary for the generation of white blood cells called T follicular helper (TFH) cells in response to a …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project developed patient-focused educational materials for the sickle cell community.
… by a change in the gene that produces hemoglobin, the red blood cells that carry oxygen throughout the body. In December … carriers for sickle cell disease have higher risks of blood clots across diverse ancestries September 12, 2024 …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… stem cell) and change it into different types of cells in the body. … Called induced pluripotent stem cells (iPSCs), this technique opens the doors to medical … a healthy person and the second set from a person with a blood disease called familial platelet disorder. Using skin …