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Dr. Shawn Burgess is the co-deputy director of NHGRI's Intramural Research Program.
… of a large effort to develop insertional mutagenesis in zebrafish, coupled with a genetic screen to identify genes … on developing efficient gene knockout technologies in zebrafish, coupled with efficient phenotyping of the gene … the vertebrate model organisms mouse ( Mus musculus ) and zebrafish ( Danio rerio ) have also been sequenced, they …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… humans. They edit the genomes of animals, like mice and zebrafish, because animals have many of the same genes  as … just this. The Burgess lab , for example, is studying zebrafish genomes. Scientists in this lab delete different genes in zebrafish one at a time using CRISPR to see how the deletion …
News Release
Baylor College of Medicine. Houston and the Medical College of Wisconsin, Milwaukee will be providing DNA sequencing for the Undiagnosed Diseases Network.
… Principal Investigator: Shuo Lin, Ph.D. By developing a zebrafish model of undiagnosed disease genes, researchers … The researchers will make observations of the outcome in zebrafish from inserting mutations in genes that have a … Diane Slusarski, Ph.D. Researchers will use a zebrafish model to explore the function of 15 gene mutations …
Jobs at NHGRI
Funded postdoctoral positions are available in the laboratory of Dr. Shawn Burgess, within NHGRI's Translational and Functional Genomics Branch.
… wound healing with an emphasis on hearing regeneration in zebrafish. There are multiple projects available to pursue … flow cytometry, cytogenetics, and transgenic mouse and zebrafish cores, allowing for broad opportunities and wide … microscopy, genetics and genomics. Experience with zebrafish is a plus but not essential. Interest in and …
News Release
Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.
… involved in T2D, the researchers studied its effects on zebrafish pancreas. The pancreas is one of the key organs … DNA editing system to make the ZRANB3 gene inoperative in zebrafish (called a ‘knockout’). They also used biological … to reduce the expression of the ZRANB3 gene in different zebrafish. In both cases, researchers observed a reduction in …
Intramural Training Office
In NIH's annual Three-Minute Talks (TmT) competition, postbaccalaureate researchers, graduate students, and postdoctoral fellows from each institute’s intramural research program have to describe their research clearly and engagingly in just three minutes using one PowerPoint slide. The competition challenges trainees to develop their communication skills as they explain the background, key findings, and significance of their work.
… three transporters: Exploring vitamin B12 deficiency using zebrafish Tara Desporte Postbaccalaureate Fellow, Brody Lab … …
News Release
NIH recently awarded approximately $6.8 million in grants to several research teams to study the biology of rare and undiagnosed diseases.
… At the Model Organisms Screening Center, scientists use zebrafish and fruit flies as models to examine how … in UDN patients. Scientists genetically modify the zebrafish and fruit fly to study the gene variant in … gene variant or turn off the gene activity of a similar zebrafish or fly gene variant, and watch the resulting …
News Release
Scientists drafted the blueprint for how to build a common goldfish. Now they'll use it to find out what gives ornamental goldfish their nuanced features, gaining insight into human health.
… the National Human Genome Research Institute, works with zebrafish. He wanted to compare their genome to closely … genomes is not much better than comparing genomes between zebrafish and humans. So, Burgess and his friend honed in on … useful in comparative genomics and also add value to the zebrafish genome. So, his friend made an offer: I'll give you …
News Release
Four NHGRI researchers share the steps toward a career in genomics with 60 Brooklyn-area high school students.
… such as gene knockdown and gene sequencing in NHGRI's Zebrafish Core. He talked about zebrafish and why they are a good model for studying human …
News Release
Researchers have identified genomic mutations for Carey-Fineman-Ziter syndrome, a congenital myopathy with facial weakness, a cleft palate and scoliosis.
… Alessandro Di Gioia, Ph.D., and Dr. Engle, generated zebrafish with a mutated mymk gene. Affected mutant zebrafish were smaller and had abnormal muscle development … mutations. The researchers were able to correct affected zebrafish's muscles by injecting the normal human MYMK gene …