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Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical building … Sequencing DNA means determining the order of the four … the pairing also underlies the methods by which most DNA sequencing experiments are done. The human genome contains about 3 billion base pairs that spell out the …
Research Funding
GS-IT provides sequence analysis tools and software to scientists who rely on genomics in their research.
… Genome Sequencing Informatics Tools (GS-IT) provides "researcher … Genome Sequencing Informatics Tools … Genome Sequencing Informatics Tools …
Infographic
An infographic that explains why it was so difficult to fully complete the human genome sequence.
… Why was it so difficult to fully complete the human genome sequence? The Human Genome Project ended in 2003, but genomic researchers had not … yet determined every last base (or letter) of the human genome sequence. Instead, they had only completed about 92% … The human genome contains a massive amount of DNA. The human genome …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
… The NIH Intramural Sequencing Center (NISC) sits on the top floor of a research … essentially unchanged in >20 years: provide contemporary genome-sequencing capabilities for intramural researchers at … to that mission, regularly generating large amounts of genome-sequence data and analyses for numerous NHGRI and NIH …
The Genomics Landscape
In the July 2019 edition of The Genomics Landscape, NHGRI Director Eric Green reflects on the milestones of the Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT) Program as it reaches completion.
… The Genome: Unlocking Life's Code exhibition is currently … of Child Health and Human Development (NICHD), the Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT) … and opportunities associated with the possible use of genome sequence information in the care of newborns. …
News Release
NHGRI will fund a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases.
… The National Institutes of Health will fund a set of genome sequencing and analysis centers whose research will focus on … The National Human Genome Research Institute (NHGRI), part of NIH, today … for Common Disease Genomics (CCDG), which will use genome sequencing to explore the genomic contributions to common …
The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… The Genome: Unlocking Life's Code exhibition is currently … Research studies that generate genome-sequence data rely on a reference sequence for making … were difficult to “read out” completely using the DNA-sequencing methods available at that time. In addition, the …
News Release
Scientists have published the first complete, gapless sequence of a human genome, two decades after the Human Genome Project produced the first draft human genome sequence.
… published the first complete, gapless sequence of a human genome, two decades after the Human Genome Project produced the first draft human genome sequence. … included leadership from researchers at the National Human Genome Research Institute (NHGRI), part of the National …
News Release
Ten investigators will receive exome sequencing data as part of their clinical research projects at the NIH Clinical Center.
… Ten intramural investigators will receive exome sequencing data as part of their clinical research projects … research. CCGO is co-sponsored by the National Human Genome Research Institute (NHGRI), the NIH Deputy Director … of gene mutations and phenotypes in a well-defined, pediatric, neuromuscular disorder cohort. Brian P. Brooks, …
Clinical Research
This team-based clinical service is provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
… by NHGRI to Intramural Investigators employing exome/genome sequencing to accomplish their research goals. The SGFS will annotate de-identified research exome/genome data for the presence of possible actionable secondary … by NHGRI to Intramural Investigators employing exome/genome sequencing. …