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News Release
A repurposed cancer drug appears to reduce the severity of lesions and pain experienced by people with Proteus syndrome
… Jeannine Mjoseth … A repurposed cancer drug appears to reduce the severity of lesions and … goal in using the drug was very different from its use in cancer therapy. In cancer, the objective is to eliminate all cancerous cells …
News Release
NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
… in tumor DNA that occurs in five different types of cancer. They also found evidence that this methylation signature may be present in many more types of cancer. The specific signature results from a chemical … in 13 different organs and deemed it a possible universal cancer biomarker. Biomarkers are biological molecules that …
Talking Glossary
A cancer-susceptibility gene is a gene that, when changed (or mutated), gives an individual an increased risk for developing cancer
… Cancer-Susceptibility Gene … A cancer-susceptibility gene is a gene that, when changed (or … gives an individual an increased risk for developing cancer … A cancer-susceptibility gene is a gene that, when …
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that contribute to cancer susceptibility and progression. … The branch focuses … and somatic (body cell) mutations that contribute to cancer susceptibility syndromes and to the development of …
Talking Glossary
Un gen de susceptibilidad al cáncer es un gen que, cuando cambia (o muta) confiere a la persona un mayor riesgo de desarrollar cáncer.
… a la persona un mayor riesgo de desarrollar cáncer. … A cancer-susceptibility gene is a gene that, when changed (or … gives an individual an increased risk for developing cancer. Individuals who have inherited mutations in certain cancer-susceptibility genes have a lifetime risk of cancer …
Educational Resources
Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male reproductive system.
… Prostate Cancer … Prostate cancer is a disease characterized by uncontrolled cell growth … gland, which is part of the male reproductive system. … Cancer, Cell, Mitosis, Mutation … Prostate cancer is a …
News Release
NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.
… from over 10,000 tumors representing 33 types of cancer. … More than 10,000 Tumors Analyzed "This project is … Francis S. Collins, M.D., Ph.D. "This analysis provides cancer researchers with unprecedented understanding of how, … informed clinical trials and future treatments." The Pan-Cancer Atlas, published as a collection of 27 papers across a …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
… the field of genomics.  …  After more than a decade, The Cancer Genome Atlas (TCGA) program is drawing to an end. A … initiated and supported by NHGRI and the National Cancer Institute (NCI), with over $300 million in total … mission to catalog the genomic changes underlying multiple cancer types. Ambitious in scope from the beginning, TCGA was …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… The Cancer Genome Atlas (TCGA) was a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research …  TCGA study improves understanding of genetic drivers of thyroid cancer  (2014)  Rare kidney tumor provides insights …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… switch from a different genetic neighborhood, turning on a cancer-growth gene. The research team was led by Bradley E. … in energy production, seemed to have no relevance to cancer. Dr. Bernstein and his colleagues found that when the IDH gene was mutated, particular portions of the cancer cells' DNA became studded with chemical tags called …