Search Results
Clinical Research
MINI Section invites caregivers of children with mitochondrial disease to participate in a survey about the use of immune therapies in children with mitochondrial disease.
… In collaboration with the UMDF, the NIH Metabolism, Infection and Immunity (MINI) Section invites caregivers of …
Educational Resources
AIDS is a collection of symptoms known as acquired immunodeficiency syndrome.
… as acquired immunodeficiency syndrome. It is caused by infection with the human immunodeficiency virus (HIV), which …
Educational Resources
A retrovirus is a virus that uses RNA as its genetic material.
… is a virus that uses RNA as its genomic material. Upon infection with a retrovirus, a cell converts the retroviral …
Fact Sheet
Genomic research has been central to understanding and combating the SARS-CoV-2 (COVID-19) pandemic.
FAQ
Addressing the COVID-19 pandemic and what it means to the pediatric mitochondrial disease community.
… may not be able to produce enough energy to help fight the infection. Tissues and organs affected by mitochondrial … The Metabolism, Infection and Immunity (MINI) Section’s mission is to understand how infection causes life-threatening illness or decline in … with mitochondrial disease from the harmful effects of infection. Vaccination is also standard of care for this …
For Patients and Families
Neglected diseases are conditions that inflict severe health burdens on the world's poorest people.
… people, mostly in Latin America. Hookworm. Human hookworm infection is caused by intestinal worm parasites transmitted … America and Australia. Yaws. This disease is a bacterial infection that affects mainly the skin, bone and cartilage. … involve giving people medications that will prevent infection or greatly minimize the impact of infection if it …
Genetic Disorders
Severe Combined Immunodeficiency is a severe, genetic condition of the immune system.
… lymphocytes to mature, proliferate and mobilize to fight infection. The defective part of the lymphocyte receptor is … component for mobilizing the body's defenses against infection. Because females have two X chromosomes, if they … lack of specific antibodies after vaccination or a natural infection are characteristic features of SCID. …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… is an immune response (for example, in the event of an infection). Pyrin increases inflammation and the production … in the MEFV gene. Mutated pyrin does not need an infection or other immune trigger to be activated; rather, it … "The mutant pyrin may be protecting them from some fatal infection." The team turned to Yersinia pestis , the infamous …
News Release
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
… T follicular helper (TFH) cells in response to a viral infection. These TFH cells then interact with another type of … causes "a severe defect" in the TFH cell response to viral infection, they concluded. "This provides new insights into … for the T Follicular Helper Cell Response to Viral Infection. Cell Reports , 12(12):2099-110. 2015. [ PubMed ] …
The Genomics Landscape
In the January 2024 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Dr. Adam Phillippy as the founding director of the Center for Genomics and Data Science Research (CGDSR).
… this mouse model presented a more human-like model of infection. Overall, the study showed the feasibility of …