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Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that contribute to cancer susceptibility and progression. … and somatic (body cell) mutations that contribute to cancer susceptibility syndromes and to the development of … cancers, including prostate, endometrial, bladder, lung, head and neck, and gastric cancers. They also study the …
News Release
How well cancer patients fare after chemotherapy can be affected by their social interaction with other patients during treatment.
… How well cancer patients fare after chemotherapy can be affected by … Cancer patients were a little more likely to survive for five … out to see if the impact of social interaction extended to cancer patients undergoing chemotherapy. Joining this … role in disease outcomes," said Dr. Koehly. "As cancer care moves more towards targeted therapies based on …
News Release
NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
… in tumor DNA that occurs in five different types of cancer. They also found evidence that this methylation signature may be present in many more types of cancer. The specific signature results from a chemical … steps that uncovered telltale methylation marks in colon, lung, breast, stomach and endometrial cancers. They showed …
News Release
A repurposed cancer drug appears to reduce the severity of lesions and pain experienced by people with Proteus syndrome
… A repurposed cancer drug appears to reduce the severity of lesions and … goal in using the drug was very different from its use in cancer therapy. In cancer, the objective is to eliminate all cancerous cells … Cancer drug reduces pain, improves symptoms in people with …
Educational Resources
Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male reproductive system.
… Prostate Cancer … Prostate cancer is a disease characterized by uncontrolled cell growth … Cancer, Cell, Mitosis, Mutation … Prostate cancer is a disease characterized by uncontrolled cell growth … which is part of the male reproductive system. Prostate cancer generally affects men over the age of 50. It is …
Talking Glossary
Un gen de susceptibilidad al cáncer es un gen que, cuando cambia (o muta) confiere a la persona un mayor riesgo de desarrollar cáncer.
News Release
NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.
… from over 10,000 tumors representing 33 types of cancer. … Francis S. Collins, M.D., Ph.D. "This analysis provides cancer researchers with unprecedented understanding of how, … informed clinical trials and future treatments." The Pan-Cancer Atlas, published as a collection of 27 papers across a …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
…  After more than a decade, The Cancer Genome Atlas (TCGA) program is drawing to an end. A … initiated and supported by NHGRI and the National Cancer Institute (NCI), with over $300 million in total … genomic changes in three types of human cancers: brain, lung, and ovarian cancer. After a successful pilot phase, …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… The Cancer Genome Atlas (TCGA) was a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research … More information on TCGA can be found on NCI’s The Cancer Genome Atlas Program website . The Cancer Genome Atlas … novel genomic changes in the most common type of lung cancer r  (2014)  TCGA bladder cancer study reveals …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… She conducted her postdoctoral training at Fox Chase Cancer Center, Philadelphia, before joining Harvard Medical … on the fine-mapping of genomic deletions in ovarian cancer and in malignant mesothelioma as a means to home in on … explain the dramatic clinical responses of non-small cell lung cancer patients to gefitinib, a small molecule inhibitor …