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News Release
Researchers find weaker immune response to viral infections in children with mitochondrial disorders
NIH researchers analyzed the gene activities of immune cells in children with mitochondrial disorders and found that their B cells, which produce antibodies to fight viral infections, are less able to survive cellular stress.
… genetic condition, immune system, sequencing, children, virus, mitochondrial, B cells, antibodies … NIH researchers …
Genetic Disorders
Severe Combined Immunodeficiency is a severe, genetic condition of the immune system.
Talking Glossary
Los ácidos nucleicos son biomoléculas grandes que cumplen funciones esenciales en todas las células y virus. Una función importante de los ácidos nucleicos implica el almacenamiento y la expresión de información genómica.
… que cumplen funciones esenciales en todas las células y virus. Una función importante de los ácidos nucleicos implica … que cumplen funciones esenciales en todas las células y virus. Una función importante de los ácidos nucleicos implica …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… who have designed gene therapies using an adeno-associated virus (AAV) as a vector to deliver the corrected gene to a … … Gene therapy, gene therapy and cancer, adeno-associated virus, AAV, methylmalonic acidemia, MMA, Charles Venditti …
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… where Dr. Chandler’s research focused on adeno-associated virus (AAV) gene therapy for the treatment of hemophilia A, a … CP. Central nervous system-targeted adeno-associated virus gene therapy in methylmalonic acidemia . Mol Ther … Project: Increasing the efficiency of adeno-associated virus gene therapy clinical trial startup . Hum Gene Ther. …
Talking Glossary
Un vector, en lo que se relaciona a la biología molecular, es una molécula de ADN (con frecuencia un plásmido o virus) que se utiliza como vehículo para transportar un segmento particular de ADN al interior de la célula huésped como parte de una técnica de clonación o ADN recombinante.
… es una molécula de ADN (con frecuencia un plásmido o virus) que se utiliza como vehículo para transportar un … to molecular biology, is a DNA molecule (often plasmid or virus) that is used as a vehicle to carry a particular DNA … es una molécula de ADN (con frecuencia un plásmido o virus) que se utiliza como vehículo para transportar un …
Fact Sheet
Genomic research has been central to understanding and combating the SARS-CoV-2 (COVID-19) pandemic.
… COVID-19 PCR tests use primers that match a segment of the virus’s genetic material. This allows many copies of that … to be made, which can be used to detect whether or not the virus is present. A positive COVID-19 PCR test means that … could either mean that the sample did not contain any virus or that there is too little viral genetic material in …
News Release
Investigators with The Cancer Genome Atlas have discovered genomic differences in head and neck cancers caused by infection with the human papillomavirus.
… (HPV). HPV is the most common sexually transmitted virus in the United States, and the number of HPV-related …
Fact Sheet
Ribonucleic acid (RNA) is an essential molecule that performs many roles in the cell, from carrying the instructions to make proteins to regulating genes.
… a protein (or piece of a protein) that is found in a virus. When the mRNAs enter cells in the body, the cells use the mRNAs to produce virus proteins and display them to the immune system. This teaches the immune system to recognize the virus, promoting a strong response if the immune system …
The Genomics Landscape
In the April 2020 edition of The Genomics Landscape, NHGRI Director Eric Green provides an update on the final stage of the Genomics2020 strategic planning process; the NIH website for COVID-19 information, the Gene documentary debut on PBS and more.
… below describes some useful information sources about the virus and some specific resources for NIH grantees and … available that provide relevant information basics of the virus (and the disease it causes), such as those at the …