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News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… changes that lead to certain blood cancers, such as leukemia. Although Dr. Liu acknowledged that the zebrafish is not a proven model for leukemia, its transparent embryos develop in the water away …
Archive
… Researchers discover key mutation in acute myeloid leukemia … Archive …
Staff
Dr. Amanda Ombrello is a clinical researcher in the Inflammatory Disease Section of NHGRI's Medical Genetics Branch.
… AK . Cryopyrin-associated periodic syndrome caused by a myeloid-restricted somatic NLRP3 mutation . Arthritis …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… vessels, resulting in lung tissue damage that causes acute chest syndrome, pain episodes, stroke and priapism … treated with hydroxyurea also have fewer attacks of acute chest syndrome and need fewer blood transfusions. Bone …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… hope to develop new therapies to treat patients with leukemia using their own iPSCs. We encourage other …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… cancers, sarcomas, colon cancers, bladder cancers and leukemia. Future studies are looking towards detecting the …
Genetic Disorders
Wilson disease is a rare genetic condition that causes a person's body to store too much of the mineral copper, leading to organ damage that may cause death.
… a protein which contains copper. However, in people with acute liver failure caused by Wilson disease, copper levels … health. However, for patients who have severe cirrhosis, acute liver failure or other serious liver disorders, a liver …
Research Funding
NSIGHT explores the implications, challenges and opportunities with the use of genomic sequence information in the newborn period.
Research Funding
A list of members who contribute to the goals of the IGVF Consortium by generating data and/or analyses, sharing data and/or analyses freely through the IGVF Data and Administrative Coordinating Center (DACC), and/or by contributing to cross- consortium integrative analyses.
… non-coding sequence variation associated with pediatric leukemia. We plan to dissect non-coding regulatory elements … genes and describe their function in hematopoiesis and leukemia.  Tychele Turner, Washington University in St. …
For Patients and Families
​Genetic research is creating new ways for people to take action and prevent disease and new ways to treat disease through personalized medicine.​ ​
… in tumors. Children with a common type of childhood leukemia can be tested to find the right doses of …