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News Release
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
… that a transcription factor known as TCF1 (for T cell factor-1) is essential for the creation and persistence … TFH cells then interact with another type of white blood cell - called B cells - that actually produce the antibodies. … TCF1 deficiency causes "a severe defect" in the TFH cell response to viral infection, they concluded. "This …
Educational Resources
A phenotype is an individual's observable traits, such as height, eye color, and blood type.
… Gene, Heterozygous, Homozygous, Allele, Trait, Genotype …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… developed the breakthrough technique to return any adult cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body. … doors to medical advances, including generating cartilage cell tissue to repair knees, retinal cells to improve the …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… In the largest genomics study of clear cell endometrial cancer (CCEC) tumors to date, National Human … survival rate. "Genomic mutations that contribute to clear cell endometrial cancer can vary from one patient to … commonly diagnosed gynecological cancer. Women with clear cell endometrial cancer, a rare type of endometrial cancer, …
Educational Resources
X-linked, as related to genetics, refers to characteristics or traits that are influenced by genes on the X chromosome.
… X Chromosome, Y Chromosome, Phenotype, Fragile X Syndrome, Trait …
Talking Glossary
Cell-free DNA testing is a laboratory method that involves analyzing free (i.e., non-cellular) DNA contained within a biological sample, most often to look for genomic variants associated with a hereditary or genetic disorder.
… Cell-Free DNA Testing … Cell-free DNA testing is a laboratory method that involves … Cell-free DNA testing is a laboratory method that involves … a hereditary or genetic disorder. For example, prenatal cell-free DNA testing is a non-invasive method used during … DNA that is naturally present in the maternal bloodstream. Cell-free DNA testing is also used for the detection and …
Educational Resources
Sex linked is a trait in which a gene is located on a sex chromosome.
… Sex linked is a trait in which a gene is located on a sex chromosome. … Cell, Mutation, Gene, Sex Chromosome … Sex linked is a trait in which a gene is located on a sex chromosome. …
Event
Future Webinar Series
… of genetics and genomics is to decompose the sources of trait variation into constituent causal factors. The hope is … the interplay of genetic and non-genetic factors in trait variation. Following on the heels of NHGRI’s workshop … challenges for delineating and understanding human complex trait genetics.  Format A series of one-hour live webinars …
Fact Sheet
Learn about the different types of hemoglobin.
… To understand sickle cell disease and gene therapy , you should first know about … Hemoglobin types and sickle cell disease  Your red blood cells contain hemoglobin , a … body to instead make hemoglobin A. For individuals with sickle cell disease, a small amount of HbF continues to be …
Educational Resources
Apoptosis is the process of programmed cell death.
… Apoptosis is the process of programmed cell death. … Programmed Cell Death, Development, DNA Repair, Cancer, Tumor, Cell Division … Apoptosis is the process of programmed cell death. It is used during early development to eliminate … is for some reason prevented, it can lead to uncontrolled cell division and the subsequent development of a tumor. …