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Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
… Humans share most of their genes with mice. Because of this, the laboratory mouse has served as a … can then observe the characteristics of knockout mice to obtain information to help researchers better … comprehensive and public resource comprised of null mutant mice and their phenotype information. As part of the …
Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… Devlin EE, Dacosta L, Mohandas N, Elliott G, Bodine DM. A transgenic mouse model demonstrates a dominant negative … of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced …
News Release
NIH researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced.
… mouse model. Scientists often use different strains of mice as animal models to study human diseases because most genes in humans have similar counterparts in mice. “A mouse model that more precisely captures the … a byproduct of how the model was developed. Humans and mice have very similar genomes, but the chromosomes that make …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… promise.   Researchers used bioengineering to create mice with a human gene that produces the defective hemoglobin … the defective hemoglobin gene was removed from the mice and genetically "corrected" by the addition of the … The corrected marrow was then transplanted into other mice with sickle cell disease. The genetically corrected mice …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… of different model organisms are used in this regard, but mice are especially useful because they share mammalian …
News Release
NHGRI researchers identified 59 genes or gene regions linked to canine athletics.
… muscle endurance by reducing pain. In a previous study in mice, researchers discovered that the ASIC3 gene is linked to … gene, which have been linked to hearing impairment in mice and humans, were significantly more common in sport … behaviors, hyperactivity and panic responses in mice ( SHANK2 and OXR1 genes) were also more prevalent in …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… this hypothesis, the researchers genetically engineered mice with FMF-causing genomic variants. They infected both healthy and genetically engineered mice with Yersinia pestis . Their results showed that infected mice with the FMF-causing genomic variant had significantly …
News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… nearly 6,000 experiments –– 4,834 in humans and 1,158 in mice –– to illuminate details of the genes and their … biochemical changes that occur during mouse development. Mice, due to their genomic and biological similarity to … human biology and disease. These experiments in humans and mice were carried out in several biological contexts. …
Infographic
The X chromosome is part of sexual development and many other biological processes, including how some cats get their distinctive coat colors.
…  The X chromosome plays a key function in aging. Mice with an XX genotype live longer than mice with XY, even if they have testes!   The X chromosome …
Staff
Dr. Lisa Helbling Chadwick is a deputy director in Division of Genome Sciences at the National Human Genome Research Institute. ​
… HF. Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval . Genetics , … influences on X chromosome choice in Xce heterozygous mice . Mamm Genome, 16(9):691-9. 2005. …