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Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… positional cloning of mib, a gene in the Notch pathway in zebrafish. Mutations in mib result in increased neural … to neurons during embryonic development, leading to the zebrafish mind bomb phenotype. In a collaborative effort in … lab further investigated the expression of menin in mouse, zebrafish and drosophila development, and they also …
Staff
Dr. Brian Brooks is an adjunct investigator in NHGRI's Center for Precision Health Research.
… Brooks BP. Aldh7a1 regulates eye and limb development in zebrafish. PLoS ONE , 9:e101782. 2014. [ PubMed ] Johnston … A, Brooks BP. Nlz1 is required for cilia formation in zebrafish embryogenesis. Dev Biol, 406:203-211. 2015. [ …
Educational Resources
An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans.
… disease found in humans. Animal models (e.g., mice, rats, zebrafish and others) are sufficiently like humans in their …
News Release
NIH researchers have developed and released an innovative software tool, called Verso, to assemble truly complete (i.e., gapless) genome sequences from a variety of species. The software makes the process of assembling complete genome sequences more affordable and accessible.
… commonly used in research, such as mice, fruit flies and zebrafish, improving their usefulness to scientists. …
Research Funding
​The Undiagnosed Diseases Network accelerates discovery and innovation in how we diagnose and treat patients with previously undiagnosed diseases.
… and a new Model Organisms Screening Center increasing the zebrafish modeling capacity and adding C. elegans  as a new …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… the petri dish and in nonhuman organisms such as mice or zebrafish. Researchers rely on genome editing tools as a way …
News Release
NHGRI researchers will present four platform talks and 55 posters to highlight the institute's diverse portfolio at the 65th annual meeting of ASHG.
… (Metabolic Disorders) *2271T. Oleg Schelochkov: A Zebrafish Knockout of Argininosuccinate Lyase Separates … and Polygenic Disorders) 1147F. Katherine Schaffer: Using zebrafish to model the role of GEMIN5 in neurological …
News Release
Researchers have conducted the first study to look at the genomic underpinnings of obesity in continental Africans and African Americans.
… experiments using cell lines and model organisms such as zebrafish to identify the role of genomic variants in SEMA4D …
The Genomics Landscape
In the January 2024 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Dr. Adam Phillippy as the founding director of the Center for Genomics and Data Science Research (CGDSR).
… researchers create genetic atlas detailing early stages of zebrafish development Notable accomplishments in genomic …
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… damaged liver. Some other animals, such as salamanders and zebrafish, can replace entire limbs and replenish a variety …