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Event
On February 16, 2023, the National Human Genome Research Institute (NHGRI) held a follow-up working group consultation after the 14th Genomic Medicine meeting, Genomic Medicine XIV: Genomic Learning Healthcare Systems.
… It almost never gets used. We have CDS for >30 gene-drug pairs in our EHR; this may be relevant, but is not … a consultservice. We have a physician who is expert in drug interactions and PGx, Tom Callaghan, M.D., Ph.D., who has a special clinic setup for difficult cases of drug therapy adverse events and consults for PGx. In our …
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… impact on clinical care . Initial findings focusing on 5 drug -gene interactions have identified one or more … kidney disease, rapid declines in renal function, CHD, drug -induced liver injury Northwestern University 11,000; …
For Health Professionals
The ISCC-PEG Pharmacogenomics (PGx) Project Group has developed peer-reviewed online education for healthcare practitioners to advance pharmacogenomics in clinical practice.
… evidence-based pharmacogenomic resources from the Food and Drug Administration (FDA), the Clinical Pharmacogenetics … safety of psychiatric medications as well as the impact of drug-drug interactions (phenoconversion) through case-based …
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… of DNA diagnostics for communicable disease . .86 5.2.4 Drug-resistant organisms . . . . . . . . . . . . . . . . . . … genes, is already starting to provide new targets for drug therapy. For example, such knowledge has led to the … Problems of Developing Countries It is not often that a drug development process is as rapid or involves as many …
Staff
Dr. Ayo Doumatey is a Research Fellow and Laboratory Manager at NHGRI's Center for Research on Genomics and Global Health.
The Genomics Landscape
In the January 5, 2023 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., talks about how artificial intelligence and machine learning are becoming omnipresent throughout NHGRI and in genomics.
… can impact physical traits such as risk of disease or drug toxicity. In this paper (Surendren et al., 2022), … of proteins that are potentially related to adverse drug effects or other health outcomes.  This research was …
Healthcare Provider Genomics Education Resource
An FAQ designed to help healthcare professionals understand the diverse landscape of direct-to-consumer (DTC) genetic testing and the benefits and limitations of these tests.
… genetic testing (DTC-GT). FDA = Food and Drug Administration; GAO = US Government Accountability … 2007: DTC-GT was offered at $1,000.  2010:  The Food and Drug Administration (FDA) initiated regulatory proceedings … clearance for a pharmacogenetics report for interpretive drug information for two medications — clopidogrel and …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… to lung cancer may be associated with the T790M drug resistance mutation in EGFR . Nat Genet, 37:1315-1316. …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… in disease etiology, health disparities and variable drug response. His lab develops genetic epidemiology models … candidate genes for BP regulation, and the latter is a drug target for a class of calcium channel blockers . The AA … and environmental basis of disease susceptibility and drug responses in Africans. Dr. Rotimi's contribution to this …
Clinical Research
A study with the goal of finding the genetic cause of familial Mediterranean fever (FMF) and several novel and undiagnosed causes of autoinflammatory disease.