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News Release
New grants totaling approximately $29.5 million will enable scientists to generate and maintain the most comprehensive reference sequence of the human genome.
… by helping them interpret both research and patient genome sequences,” said Adam Felsenfeld, Ph.D., NHGRI program … use the reference genome sequence to assemble genome sequences from individuals. By advancing the quality of the … state-of-the-art technologies to incorporate high-quality sequences that are more broadly representative. The amount of …
Staff
Dr. Gerard Bouffard directs the Bioinformatics Group at the NIH Intramural Sequencing Center (NISC).
… W., Green E.D. Comparative analyses of multi-species sequences from targeted genomic regions. Nature, … Context-dependent Mutation Rates Using Primate Genomic Sequences. J Mol Evol , 65(3):207-14. 2007. [ PubMed ] Grice … ED. Effort required to finish shotgun-generated genome sequences differs significantly among vertebrates. BMC …
Staff
Dr. Mullikin was the former director of the NIH Intramural Sequencing Center (NISC).
… ] Yuhki N, Mullikin JC, Beck T, Stephens R and O'Brien SJ. Sequences, annotation and single nucleotide polymorphism of …
Media Advisory
The National Institutes of Health (NIH) will host researchers from the Telomere-to-Telomere (T2T) consortium, who have now sequenced the remaining 8% of DNA that was unable to be sequenced by the Human Genome Project and has eluded researchers for nearly two decades.
News Release
A team of NIH-funded researchers have generated the first complete chromosome sequences from non-human primates.
… Complete X and Y chromosome sequences from six primate species reveal species diversity … of Health have generated the first complete chromosome sequences from non-human primates. Published in Nature , these sequences uncover remarkable variation between the Y …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… coding regions of the genome. This information - found in sequences of DNA - controls genes by turning them on and off, … differs among individuals. "We know that the regulatory sequences - switches - are incredibly context specific. They … of Excellence in Genomic Science, CEGS, Jeffery Schloss, requlatory sequences, epigenomes, mouse embryonic stem cells, …
Educational Resources
Cloning is the process of making identical copies of an organism, cell, or DNA sequence.
Clinical Research
This team-based clinical service is provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
The Genomics Landscape
In the April 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the Telomere-to-Telomere (T2T) consortium's publishing of a collection of papers that reported the first truly complete sequence of the human genome.
… its first genomic dataset , including whole-genome sequences from nearly 100,000 participants from diverse … first genomic dataset of nearly 100,000 whole genome sequences All of Us: Release of nearly 100,000 whole genome sequences sets stage for new discoveries Notable …
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… Collection (MGC), a program that generated high-quality sequences of a reference set of cDNA clones representing …