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NSIGHT explores the implications, challenges and opportunities associated with the possible use of genomic sequence information during the newborn period.
… to explore the implications, challenges and opportunities associated with the possible use of genomic sequence … explores the implications, challenges and opportunities associated with the possible use of genomic sequence … explores the implications, challenges and opportunities associated with the possible use of genomic sequence …
Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… Leja, NHGRI.  Dr. Bell and her team isolated DNA from tumor cells and from normal cells from patients with CCEC. Their goal was to identify genetic mutations in CCEC tumor cells that are absent from normal cells. The team … implicated in CCEC. TAF1 encodes part of a transcription factor complex, which regulates the expression of other genes …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… are located. Initially, they showed that two different tumor sample storage methods produced comparable DNA … and spoke to experts to develop a database of 121 tumor genomic alterations that could have therapeutic, … interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nature …
Staff
Lindsey Criswell, who became the director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases in February, 2021 is also an associate investigator in NHGRI's Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… (RA); systemic lupus erythematosus (SLE), Sjögren’s syndrome, major histocompatibility complex (MHC), biological …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
… the bladder. … Age: A man's age is the strongest risk factor for prostate cancer. It is rare for a man to develop … Environmental Factors: Environmental risk factors are associated with developing prostate cancer. These are: … is slow. Surgery may be another treatment used if the tumor has not spread to other parts of the body and the man …
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… that the molecular mechanisms of disease differ across tumor types. Furthering the complexity of regulated gene … in tumors, characterized by extensive methylation of the tumor phenotype. The Elnitski group identified a methylator … P.J., Jones, S.J. Locating mammalian transcription factor binding sites: A survey of computational and …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice … of gene therapy … NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated …
Talking Glossary
Genetics is the branch of biology concerned with the study of inheritance, including the interplay of genes, DNA variation and their interactions with environmental factors.
Research Funding
The PAGE Consortium investigates ancestrally diverse populations to gain a better understanding of how genetic factors influence susceptibility to disease.
… relative risks, and distribution of phenotypes associated with particular variants and their environmental …