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News Release
Investigators with The Cancer Genome Atlas have discovered genomic differences in head and neck cancers caused by infection with the human papillomavirus.
… head and neck cancers, noticeably in oropharyngeal tumors, has created an even greater sense of urgency in the … behind the mouth. "We're uncovering differences between tumors with and without HPV infection, and these new data are … the study, researchers performed genomic analyses on 279 tumors - head and neck squamous cell carcinomas (HNSCC) - …
Staff
Elaine Ostrander is chief of NHGRI's Cancer Genetics and Comparative Genomics Branch.
… the utility of dogs for cancer genetics by mapping kidney cystadeno-carcinoma in German Shepherds, prior to its … of the bladder 27, 28 , and canine transmissible venereal tumors 29 . Prostate Cancer : We have worked for the last … landscape of BRCA2-associated aggressive prostate tumors, defining a signature of an increased somatic mutation …
Research at NHGRI
CRGGH facilitates understanding of the relationship between genetic variation and population differences in disease distribution to inform health disparities.
… obesity, hypertension, diabetes, dyslipidemia, and kidney diseases, in different human populations with …
Diversity Center
Tuskegee University establishes the Carver Genomic Research Center.
… tumor microenvironment or immune contexture of the tumors However, many cancer patients do not participate in …
News Release
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.
… (which is commonly affected in cancers) in 44 percent of tumors. TP53 makes the p53 tumor suppressor protein, which … identified potential drug targets in 69 percent of the tumors evaluated. They found frequent mutations in the ERBB2 … responsible for cervical cancer - was found in bladder tumors. This suggests that viral infection can contribute to …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… somatic mutations in PI3-kinase in endometrial tumors, thus uncovering previously unrecognized cohorts of … alterations that drive clinically aggressive endometrial tumors, and to understand their functional consequences. Dr. … the genetic and genomic alterations that drive solid tumors. In her previous position at Massachusetts General …
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… treatment of high blood pressure, hypertension and chronic kidney disease. Both hypertension and high blood pressure exacerbate end-stage kidney diseases, and all three conditions are more common … L1 ( APOL1 ) gene that increase susceptibility to severe kidney disease by a factor of 10. Researchers will compare …
Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
News Release
The TCGA network describes uterine and bile duct cancer.
… uncontrolled cell growth that is the hallmark of malignant tumors. Last month, two publications from the TCGA network …