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Proteins are an important class of molecules found in all living cells.
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… large-scale analysis of all the proteins in an organism, tissue type, or cell (called the proteome). Proteomics can be … blastocyst have the ability to develop into every type of tissue (skin, liver, kidney, blood, etc.) found in an adult … patient's immune system may react and reject the donated tissue as "foreign." However, by using stem cells, there may …
News Release
Researchers funded by NHGRI’s Genome Technology Program include a wide range of investigators with a variety of scientific expertise.
… looking at the expression of a few select genes in a whole tissue or looking at more genes in cells grown in an … gene expression and understand genome function at the tissue level. To do this, the researchers built an array of … gene expression of many genes in the context of the whole tissue,” says Dr. Chen. Already, the group has applied their …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… out in an ES cell, the effects can be observed in any tissue in an adult mouse. In addition, ES cells grown in the …
Talking Glossary
RNA-seq, short for RNA sequencing, is a method for sequencing an entire set of RNA molecules.
… This method involves isolating RNA molecules in the tissue or cell sample, copying those RNAs into DNA and then …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… researchers found that differences appeared in specific tissue and cell types. "We didn't know before these results … sites (which identify regulatory DNA) in 45 mouse cell and tissue types to those in humans. They reported in Science … his colleagues compared gene expression in 15 different tissue types in mice and humans. Contrary to previous …
News Release
The skin microbiota plays an intricate role in the human immune system, directing many immune functions and defending against bacterial pathogens.
… to an immune-system receptor. S. epidermidis also inhibits tissue colonization by the highly pathogenic S. aureus , the … Among these functions are overall immune system screening, tissue repair, wound healing, inflammation control, … If S. epidermidis fails to confine S. aureus to the nasal tissue that it often inhabits, the human host could be in for …
Staff
Dr. Acosta is a board-certified pediatric neurologist with the NIH Undiagnosed Diseases Program's GM1 gene therapy trial.
… positive impact that the gene therapy may have on brain regeneration. This is especially significant, as some …
News Release
A repurposed cancer drug appears to reduce the severity of lesions and pain experienced by people with Proteus syndrome
… the researchers looked at was the cerebriform connective tissue nevus (CCTN), which is a disfiguring, massive …